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AB209976

Anti-MyoD1 抗体

Anti-MyoD1 antibody

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(3 Publications)

Rabbit Polyclonal MYOD1 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish myod1 aa 100 to C-terminus.

別名を表示する

myod, myod1, Myoblast determination protein 1 homolog, Myogenic factor 1

1 Images
IHC - Wholemount - Anti-MyoD1 antibody (AB209976)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-MyoD1 antibody (AB209976)

Immunohistochemical analysis of Paraformaldehyde-fixed whole mount Zebrafish embryos labeling MyoD1 at Somites with ab209976 at 1/200 dilution.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Zebrafish

アプリケーション

IHC - Wmt

applications

免疫原

Recombinant Fragment Protein within Zebrafish myod1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q90477

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCWmt-species-checked": "testedAndGuaranteed", "IHCWmt-species-dilution-info": "1/100 - 1/500", "IHCWmt-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MyoD1 also known as Myogenic Differentiation 1 is a master regulator of muscle differentiation. It functions mechanically as a transcription factor binding to DNA at specific sequences thereby activating the transcription of genes necessary for muscle tissue development. MyoD1 has a molecular weight of approximately 45 kDa. It is expressed in skeletal muscle tissues and also detected in some non-muscle tissues though at lower levels. MyoD1 is essential in the early stages of muscle cell lineage commitment.
Biological function summary

MyoD1 plays an important role in muscle differentiation by activating muscle-specific genes. It belongs to the myogenic regulatory factor family and often operates within a protein complex alongside Myf5 and myogenin aiding in the conversion of mesodermal stem cells into muscle cells. These partnerships enhance its ability to initiate the muscle-specific gene expression that drives myogenesis. MyoD1 acts like a molecular switch shifting cells into the pathway leading to muscle formation.

Pathways

MyoD1 is an integral component of myogenesis and muscle regeneration pathways. MyoD1 interacts with key pathway components such as Myf5 and MRF4 which reinforce MyoD1 activity in muscle tissue lineage determination and cell cycle arrest during differentiation. The activity of MyoD1 in these pathways highlights its role in skeletal muscle growth. MyoD1 also demonstrates functional redundancy with Myogenin as both share overlapping roles in these critical pathways.

MyoD1 is associated with muscular dystrophy and some sarcomas. Aberrant expression or mutations in MyoD1 can disrupt normal muscle differentiation contributing to muscle-related disorders like rhabdomyosarcoma a form of cancer comprising cells resembling skeletal muscle. Its relationship with other proteins like Myf5 further highlights its role in such pathological conditions as faults in these connections can amplify or alter disease progression.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
See full target information myod1
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 43:5635-5666 PubMed39349846

2024

Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.

Applications

Unspecified application

Species

Unspecified reactive species

Marek Kravec,Ondrej Šedo,Jana Nedvědová,Miroslav Micka,Marie Šulcová,Nikodém Zezula,Kristína Gömöryová,David Potěšil,Ranjani Sri Ganji,Sara Bologna,Igor Červenka,Zbyněk Zdráhal,Jakub Harnoš,Konstantinos Tripsianes,Carsten Janke,Cyril Bařinka,Vítězslav Bryja

RSC advances 13:14685-14697 PubMed37197682

2023

Integrated pipeline for ultrasensitive protein detection in cancer nanomedicine.

Applications

Unspecified application

Species

Unspecified reactive species

Chi-An Cheng,Li-Chiao Chiang,Yu-Syuan Chu

NPJ science of food 7:17 PubMed37149658

2023

Tissue-like cultured fish fillets through a synthetic food pipeline.

Applications

Unspecified application

Species

Unspecified reactive species

Enbo Xu,Ruihao Niu,Jihui Lao,Shengliang Zhang,Jie Li,Yiyuan Zhu,Huimin Shi,Qingqing Zhu,Yijian Chen,Yuyan Jiang,Wenjun Wang,Jun Yin,Qihe Chen,Xiao Huang,Jun Chen,Donghong Liu
View all publications
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代替製品

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MyoD1 antibody [rMYD712] (AB238025)

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Primary Antibodies

AB212662

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MyoD1 antibody [5.8A] - BSA free (AB212662)

  • 0
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Primary Antibodies

AB16148

Anti-MyoD1 antibody [5.2F]

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MyoD1 antibody [5.2F] (AB16148)

  • 3
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Primary Antibodies

AB64159

Anti-MyoD1 antibody

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  • 3
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Primary Antibodies

AB133627

Anti-MyoD1 antibody [EPR6653-131]

RabMAb|Recombinant|Lab Essentials|Advanced Validation|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MyoD1 antibody [EPR6653-131] (AB133627)

  • 4
  • 11
Primary Antibodies

AB240073

Anti-MyoD1 antibody [EPR6653-131] - BSA and Azide free

Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MyoD1 antibody [EPR6653-131] - BSA and Azide free (AB240073)

  • 0
  • 0
Primary Antibodies

AB203383

Anti-MyoD1 antibody

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MyoD1 antibody (AB203383)

  • 3
  • 3

組合せ製品

Primary Antibodies

AB124800

Anti-Myogenin antibody [EPR4789]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myogenin antibody [EPR4789] (AB124800)

  • 5
  • 3
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB37484

Anti-Myosin heavy chain antibody [A4.1025]

BOND RX™ Validated|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myosin heavy chain antibody [A4.1025] (AB37484)

  • 0
  • 0
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230

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