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AB231789

Anti-MYO1E 抗体

Anti-MYO1E antibody

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(1 Publication)

Rabbit Polyclonal MYO1E antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Myo1e aa 750-1050.

別名を表示する

MYO1C, MYO1E, Unconventional myosin-Ie, Myosin-Ic, Unconventional myosin 1E

3 Images
Western blot - Anti-MYO1E antibody (AB231789)
  • WB

Supplier Data

Western blot - Anti-MYO1E antibody (AB231789)

All lanes:

Western blot - Anti-MYO1E antibody (ab231789) at 1 µg/mL

All lanes:

Mouse liver lysate

Predicted band size: 127 kDa

false

Western blot - Anti-MYO1E antibody (AB231789)
  • WB

Supplier Data

Western blot - Anti-MYO1E antibody (AB231789)

All lanes:

Western blot - Anti-MYO1E antibody (ab231789) at 2 µg/mL

All lanes:

Recombinant mouse MYO1E protein.

Predicted band size: 127 kDa

false

Western blot - Anti-MYO1E antibody (AB231789)
  • WB

Supplier Data

Western blot - Anti-MYO1E antibody (AB231789)

All lanes:

Western blot - Anti-MYO1E antibody (ab231789) at 1 µg/mL

All lanes:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate.

Predicted band size: 127 kDa,217 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Mouse Myo1e aa 750-1050. The exact immunogen used to generate this antibody is proprietary information.

E9Q634

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab231789 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
バッファー組成
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Myosin IE (MYO1E) also known as myosin-1E is a motor protein that contributes to actin filament dynamics. It has a molecular mass of approximately 128 kDa. MYO1E is expressed in various tissues including the brain kidney and skeletal muscle. Functionally MYO1E plays a role in cellular processes such as membrane trafficking cell migration and mechanotransduction by attaching to actin filaments and using ATP to generate force and movement.
Biological function summary

MYO1E influences cellular architecture and signaling pathways important for maintaining cellular functions. This protein often associates with complexes involved in endocytosis and cytoskeletal reorganization. Through its interaction with actin MYO1E modulates the shape and movement of cells influencing processes like phagocytosis and the maintenance of cell-cell junctions. Its expression pattern and interactions suggest a role in dynamic cellular environments.

Pathways

MYO1E is integral to the regulation of the phosphatidylinositol 3-kinase (PI3K) signaling and endocytic pathways. These pathways are vital for cellular processes like growth survival and metabolism. MYO1E interacts with proteins such as PI3K and actin-related proteins that further regulate how cells respond to environmental signals and maintain homeostasis. By integrating into these pathways MYO1E affects cellular adaptation to external stimuli and internal changes.

MYO1E has links to glomerulopathy and cancer. Mutations or dysregulation of MYO1E can lead to focal segmental glomerulosclerosis a kidney disorder through disrupted interactions with nephrin and actin cytoskeletal components. Additionally abnormalities in MYO1E expression or function have implications in cancer particularly due to its role in cell migration and invasion and its connection with signaling proteins like PI3K can influence tumor progression.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Actin-based motor molecule with ATPase activity (PubMed : 11940582, PubMed : 36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed : 36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
See full target information MYO1E
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

NPJ Regenerative medicine 10:19 PubMed40253438

2025

Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval.

Applications

Unspecified application

Species

Unspecified reactive species

Lalitha Soundararajan,Harshini Surendran,Niharika Patlolla,Rajani Battu,Jonathan Stoddard,Sebastian Arrizabalaga,Zengping Liu,Gopal Lingam,Xinyi Su,Renee C Ryals,Rajarshi Pal
View all publications
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