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AB905

Anti-Mycobacterium tuberculosis 抗体

Anti-Mycobacterium tuberculosis antibody

4

(2 Reviews)

|

(25 Publications)

Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody detecting Mycobacterium tuberculosis in IHC-P.

- Over 20 publications
- Trusted since 2002

別名を表示する

M. tuberculosis

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mycobacterium tuberculosis antibody (AB905)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mycobacterium tuberculosis antibody (AB905)

Lung tissue stained with ab905 at 1/500.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mycobacterium tuberculosis

アプリケーション

IHC-P

applications

特異性

This antibody is reactive with other Mycobacteria species including: M. avium, M. phlei, and M. parafortuitum. This antibody has been reported not to be reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitides.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Candida albicans": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>ABC method.</p>" }, "Escherichia coli": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>ABC method.</p>" }, "Mycobacterium tuberculosis": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p>ABC method.</p>" }, "Salmonella typhimurium": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>ABC method.</p>" } } }
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製品の詳細

What is this antibody validated in?
Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P). Trusted by the scientific community
Anti-Mycobacterium tuberculosis (ab905) was first used in a scientific publication in 2002 and has been cited over 20 times in peer-reviewed journals.
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出荷温度及び保存条件

製品の状態
Liquid
精製度
IgG fraction
バッファー組成
Preservative: 0.1% Sodium azide Constituents: Carrier protein, PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Mycobacterium tuberculosis sometimes referred to as M. tuberculosis is a pathogenic bacterial species in the Mycobacterium genus. It is the causative agent of tuberculosis (TB) in humans and has a relatively large cellular mass characterized by a thick and complex cell wall rich in mycolic acids. This bacterium expresses in the lungs where it primarily resides in pulmonary macrophages after inhalation. The robust cell wall serves as a barrier against phagocytosis and contributes to its resistance to many antimicrobial agents.
Biological function summary

The bacteria stimulate a host immune response causing the formation of granulomas which are small nodular aggregations of immune cells. Mycobacterium tuberculosis employs several mechanisms to inhibit the lysosomal degradation processes in macrophages. It is part of a complex interplay involving the immune system which tries to control its spread. This interaction allows it to persist in a dormant state within the host making it difficult to eradicate completely and able to reactivate later.

Pathways

Mycobacterium tuberculosis's survival and pathogenicity involve several critical biological processes. The bacteria actively dodge destruction through pathways that inhibit host cell apoptosis and modulate cytokine production. Specific proteins like the 6-kda early secretory antigen target (ESAT-6) and culture filtrate protein 10 (CFP-10) complexes play a vital role in these mechanisms manipulating host immune signaling pathways to facilitate prolonged infection.

Mycobacterium tuberculosis is directly associated with tuberculosis a disease that can affect different body organs but most often targets the lungs. The pathogen’s persistence mechanisms implicate it in chronic infections and proteins like Ag85 complex interact with host defenses to further complicate control of the disease. Another disorder linked to its infection is latent TB where the bacteria remain inactive but viable within the host posing ongoing public health challenges.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Mycobacterium tuberculosis
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文献 (25)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:1430 PubMed36932056

2023

A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination.

Applications

Unspecified application

Species

Unspecified reactive species

Lihua Qiang,Yong Zhang,Zehui Lei,Zhe Lu,Shasha Tan,Pupu Ge,Qiyao Chai,Mengyuan Zhao,Xinwen Zhang,Bingxi Li,Yu Pang,Lingqiang Zhang,Cui Hua Liu,Jing Wang

Heliyon 8:e12370 PubMed36590545

2022

Utility of anti- antibody (ab905) for detection of mycobacterial antigens in formalin-fixed paraffin-embedded tissues from clinically and histologically suggestive extrapulmonary tuberculosis cases.

Applications

Unspecified application

Species

Unspecified reactive species

Samuel Ofori Addo,Afua Owusua Darkwah Abrahams,Gloria Ivy Mensah,Bernice Anane Mawuli,Lydia Mosi,Edwin Kwame Wiredu,Kennedy Kwasi Addo

Molecular medicine reports 25: PubMed35425995

2022

Estradiol inhibits autophagy of ‑infected 16HBE cells and controls the proliferation of intracellular .

Applications

Unspecified application

Species

Unspecified reactive species

Yiling Gan,Qianfang Hu,Anmao Li,Lei Gu,Shuliang Guo

Advanced healthcare materials 11:e2102640 PubMed35038229

2022

Development of a Highly Specific, Selective, and Sensitive Fluorescent Probe for Detection of Mycobacteria in Human Tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Siddhi Gupta,Deepak Kumar Mishra,Mehak Zahoor Khan,Varsha Saini,Devashish Mehta,Sandeep Kumar,Aditya Yadav,Madhurima Mitra,Parul Rani,Mukesh Singh,Chayan Kanti Nandi,Prasenjit Das,Vineet Ahuja,Vinay Kumar Nandicoori,Avinash Bajaj

Pathogens (Basel, Switzerland) 10: PubMed34959527

2021

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-Directed Therapies.

Applications

Unspecified application

Species

Unspecified reactive species

Robert E Brown,Robert L Hunter

mBio 12:e0166521 PubMed34311585

2021

Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis.

Applications

Unspecified application

Species

Unspecified reactive species

Gopinath Krishnamoorthy,Peggy Kaiser,Patricia Constant,Ulrike Abu Abed,Monika Schmid,Christian K Frese,Volker Brinkmann,Mamadou Daffé,Stefan H E Kaufmann

Cell host & microbe 29:594-606.e6 PubMed33711270

2021

TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin H Gern,Kristin N Adams,Courtney R Plumlee,Caleb R Stoltzfus,Laila Shehata,Albanus O Moguche,Kathleen Busman-Sahay,Scott G Hansen,Michael K Axthelm,Louis J Picker,Jacob D Estes,Kevin B Urdahl,Michael Y Gerner

Cell host & microbe 29:68-82.e5 PubMed33142108

2020

Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis.

Applications

Unspecified application

Species

Unspecified reactive species

Courtney R Plumlee,Fergal J Duffy,Benjamin H Gern,Jared L Delahaye,Sara B Cohen,Caleb R Stoltzfus,Tige R Rustad,Scott G Hansen,Michael K Axthelm,Louis J Picker,John D Aitchison,David R Sherman,Vitaly V Ganusov,Michael Y Gerner,Daniel E Zak,Kevin B Urdahl

Annals of clinical and laboratory science 50:429-438 PubMed32826237

2020

Morphoproteomics Identifies the Foamy Alveolar Macrophage as an M2 Phenotype with PD-L1 Expression in the Early Lesion of Post-Primary Tuberculosis: Implications for Host Immune Surveillance and Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Shen-An Hwang,Yasir Ali,Elena Fedotova,Robert L Hunter,Robert E Brown

Disease models & mechanisms 13: PubMed32034005

2020

FX11 limits growth and potentiates bactericidal activity of isoniazid through host-directed activity.

Applications

Unspecified application

Species

Unspecified reactive species

Gopinath Krishnamoorthy,Peggy Kaiser,Ulrike Abu Abed,January Weiner,Pedro Moura-Alves,Volker Brinkmann,Stefan H E Kaufmann
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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