Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
リコンビナントRabMAb

Anti-Munc18-1 抗体 [EPR4849] (ab109023)

Reviews (1) Submit a question References (2)
Western blot - Anti-Munc18-1 antibody [EPR4849] (ab109023)
  • Anti-Munc18-1 antibody [EPR4849] (ab109023)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR4849] to Munc18-1
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-Munc18-1 antibody [EPR4849]
    Munc18-1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR4849] to Munc18-1

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details
    適用なし: Flow Cyt,ICC/IF or IHC-P

  • 種交差性

    交差種: Human
    交差が予測される動物種: Mouse, Rat

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • SH SY5Y and Human fetal brain lysates; SH SY5Y cells.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab109023の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
1/1000 - 1/10000. Predicted molecular weight: 68 kDa.
特記事項
WB
1/1000 - 1/10000. Predicted molecular weight: 68 kDa.
追加情報
Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

ターゲット情報

  • 機能

    May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

  • 組織特異性

    Brain and spinal cord. Highly enriched in axons.

  • 関連疾患

    Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.

  • 配列類似性

    Belongs to the STXBP/unc-18/SEC1 family.

  • 細胞内局在

    Cytoplasm. Membrane.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • FLJ37475 antibody
    • Munc 18 1 antibody
    • Munc 18a antibody
    • MUNC18 1 antibody
    • N-Sec1 antibody
    • Neuronal SEC1 antibody
    • NSec1 antibody
    • p67 antibody
    • Protein unc-18 homolog 1 antibody
    • Protein unc-18 homolog A antibody
    • Rb sec1 antibody
    • RBSEC1 antibody
    • STXB1_HUMAN antibody
    • STXBP1 antibody
    • Syntaxin binding protein 1 antibody
    • Syntaxin-binding protein 1 antibody
    • Unc 18 homolog antibody
    • Unc 18A antibody
    • Unc-18A antibody
    • Unc18 1 antibody
    • UNC18 antibody
    • Unc18-1 antibody
    see all

画像

  • Western blot - Anti-Munc18-1 antibody [EPR4849] (ab109023)
    Western blot - Anti-Munc18-1 antibody [EPR4849] (ab109023)
    All lanes : Anti-Munc18-1 antibody [EPR4849] (ab109023) at 1/1000 dilution

    Lane 1 : SH SY5Y cell lysate
    Lane 2 : Human fetal brain lysate

    Lysates/proteins at 10 µg per lane.

    Predicted band size: 68 kDa

  • Anti-Munc18-1 antibody [EPR4849] (ab109023)
    Anti-Munc18-1 antibody [EPR4849] (ab109023)

参考文献 (2)

ab109023 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab109023 は 2 報の論文で使用されています。

  • Chirinskaite AV  et al. STXBP1 forms amyloid-like aggregates in rat brain and demonstrates amyloid properties in bacterial expression system. Prion 15:29-36 (2021). PubMed: 33590815
  • Qureshi AW  et al. Ageing enhances the shedding of splenocyte microvesicles with endothelial pro-senescent effect that is prevented by a short-term intake of omega-3 PUFA EPA:DHA 6:1. Biochem Pharmacol 173:113734 (2020). PubMed: 31811867

レビューと Q&A

Show All レビュー Q&A
レビューを送る 質問を送る

Immunohistochemistry (Frozen sections) abreview for Anti-Munc18-1 antibody [EPR4849]

 Excellent
Abreviews
abreview image
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Retina)
Permeabilization
Yes - Triton X-100 0.1 %
Specification
Retina
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 22°C
Fixative
Paraformaldehyde
Read More
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

DR. Henri Leinonen

Verified customer

投稿 Jul 01 2021

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com