AB167406

Anti-MRPS31 抗体 [EPR10707]

Anti-MRPS31 antibody [EPR10707]

RabMAb
Recombinant
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(3 Publications)

Rabbit Recombinant Monoclonal MRPS31 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

別名を表示する

IMOGN38, MRPS31, Small ribosomal subunit protein mS31, Imogen 38, MRP-S31, S31mt

1 Images

Unknown

Western blot - Anti-MRPS31 antibody [EPR10707] (AB167406)

All lanes:

Western blot - Anti-MRPS31 antibody [EPR10707] (ab167406) at 1/1000 dilution

Lane 1:

Jurkat cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

HepG2 cell lysate at 10 µg

Lane 4:

MCF7 cell lysate at 10 µg

Predicted band size: 45 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR10707

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% Ethylenediaminetetraacetic acid, disodium, dihydrate

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MRPS31 or mitochondrial ribosomal protein S31 is a component of the mitochondrial ribosome small subunit. Its molecular mass is approximately 45 kDa. MRPS31 is important in the synthesis of mitochondrial proteins since it facilitates protein translation within mitochondria. It mainly expresses in tissues with high energy demands such as muscle and brain. Mitochondrial ribosomal protein S31 is essential for maintaining mitochondrial function under different energy requirements.

Biological function summary

MRPS31 participates in the assembly and function of the mitochondrial ribosome a complex responsible for protein synthesis in mitochondria. It interacts closely with other ribosomal proteins and rRNA to ensure proper mitochondrial translation. By engaging in mitochondrial ribosome assembly MRPS31 contributes significantly to energy production and cellular metabolism supporting the high-energy needs of various types of cells.

Pathways

MRPS31 plays a significant role within oxidative phosphorylation and mitochondrial protein synthesis pathways. Oxidative phosphorylation relies on the proteins produced by the mitochondrial ribosome with MRPS31 aiding their synthesis. The mitochondrial ribosome including MRPS31 collaborates with proteins such as COX1 in the respiratory chain to ensure efficient energy generation. This integration into critical pathways emphasizes its role in cellular energy regulation and homeostasis.

MRPS31 is implicated in mitochondrial dysfunctions and neurodegenerative diseases. Mutations or dysfunctions in MRPS31 sometimes lead to disorders like mitochondrial myopathy where energy production becomes impaired. Moreover the protein's association with energy metabolism links it to Parkinson’s disease where mitochondrial deficits play a role. Direct interactions with proteins such as PINK1 in such conditions hint at its participation in disease pathogenesis and highlight its relevance in maintaining mitochondrial health.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information MRPS31

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cells 11: PubMed35805162

2022

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection.

Applications

Unspecified application

Species

Unspecified reactive species

Seongki Min,So Mee Kwon,Jiwon Hong,Young-Kyoung Lee,Tae Jun Park,Su Bin Lim,Gyesoon Yoon

Cell death & disease 12:1076 PubMed34772924

2021

MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness.

Applications

Species

Human

Seongki Min,Young-Kyoung Lee,Jiwon Hong,Tae Jun Park,Hyun Goo Woo,So Mee Kwon,Gyesoon Yoon

Scientific reports 8:9817 PubMed29959348

2018

Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients.

Applications

Species

Human

Georgina Askeland,Zaneta Dosoudilova,Marie Rodinova,Jiri Klempir,Irena Liskova,Anna Kuśnierczyk,Magnar Bjørås,Gaute Nesse,Arne Klungland,Hana Hansikova,Lars Eide

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MRPS31 抗体 [EPR10707]

Anti-MRPS31 antibody [EPR10707]

Western blot - Anti-MRPS31 antibody [EPR10707] (AB167406)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise