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AB188926

Anti-Motilin receptor 抗体 - C-terminal

Anti-Motilin receptor antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal Motilin receptor antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MLNR.

別名を表示する

GPR38, MTLR, MTLR1, MLNR, Motilin receptor, G-protein coupled receptor 38

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Motilin receptor antibody - C-terminal (AB188926)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Motilin receptor antibody - C-terminal (AB188926)

Immunohistochemistry analysis of formalin/PFA-fixed paraffin-embedded Human uterus, vessel labeling Motilin receptor tissue with ab188926 at 10μg/ml.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human MLNR. The exact immunogen used to generate this antibody is proprietary information.

O43193

特異性

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The motilin receptor also known as GPR38 is a G-protein-coupled receptor (GPCR) with a molecular mass of approximately 45 kDa. This receptor primarily binds to motilin a peptide hormone. It is expressed in the smooth muscle cells of the gastrointestinal tract notably in areas like the stomach and small intestine. By coupling with G-proteins the motilin receptor initiates intracellular signaling cascades that result in physiological responses.
Biological function summary

The motilin receptor plays an important role in regulating gastrointestinal motility. This receptor upon binding motilin triggers contractions in the smooth muscles of the digestive tract. It does not form part of a larger receptor complex and functions independently to modulate stomach and small intestine contractions. Its activity is important for the interdigestive migrating motor complex which moves undigested food through the gastrointestinal tract during fasting periods.

Pathways

Motilin receptor activation significantly impacts the motility and secretory pathways involved in gastrointestinal regulation. It interacts with other proteins in the gastrointestinal signaling network including ghrelin and gastrin to efficiently coordinate motility. The motilin receptor modulates cyclic AMP levels and calcium signaling pathways essential for smooth muscle contractions thereby assisting in coordinated gastrointestinal movements.

The motilin receptor is closely linked to gastrointestinal functional disorders such as gastroparesis and irritable bowel syndrome (IBS). Alterations in receptor activity can lead to disrupted motility and contribute to these conditions. The receptor also associates with ghrelin in the context of functional gastrointestinal disorders as both influence motility patterns. Understanding motilin receptor mechanisms can therefore inform therapeutic strategies for managing these digestive ailments.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Receptor for motilin.
See full target information MLNR
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular signalling 52:147-154 PubMed30213686

2018

Ligand-mediated dephosphorylation signaling for MAP kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Nataliia V Shults,Faisal S Almansour,Vladyslava Rybka,Dante I Suzuki,Yuichiro J Suzuki
View all publications
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