Anti-mono methyl Arginine 抗体 [16B11]

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Mono methyl arginine also known as MMA is a post-translational modification where a single methyl group is added to the guanidino nitrogen group of arginine residues. This modification is catalyzed by a group of enzymes called protein arginine methyltransferases (PRMTs). MMA exists in proteins throughout various tissues mainly in the nucleus cytoplasm and sometimes in mitochondria. This modification contributes to the molecular mass of modified proteins which varies depending on the protein itself.

Biological function summary

The process of arginine methylation which includes mono methyl arginine formation plays a role in diverse cellular functions such as signal transduction RNA processing and gene expression regulation. Mono methyl arginine often participates in forming larger protein complexes. For instance it can act as a binding site for other proteins in these complexes facilitating interactions necessary for cellular operations. It is important in the regulation of transcription factors and also influences DNA repair mechanisms.

Pathways

Mono methyl arginine is integral in the regulation of the epigenetic pathways and cellular signaling pathways such as the Ras signaling pathway. By altering the methylation status of proteins it affects protein-protein interactions and the activity of signaling molecules. This modification is closely associated with proteins like histones in epigenetic regulation and the protein Ras in signaling pathways. Through these associations it influences important cellular decisions such as differentiation proliferation and apoptosis.

Mono methyl arginine modifications have linkages with cancer and cardiovascular disorders. In cancer abnormal arginine methylation can lead to dysregulation of gene expression promoting oncogenesis. Proteins such as PRMT1 are often found deregulated in cancerous cells. In cardiovascular diseases where altered vascular tone is a significant factor mono methyl arginine has associations with endothelial dysfunction. This dysfunction can further lead to changes in the regulation of the protein endothelial nitric oxide synthase (eNOS) affecting cardiovascular health.