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AB198815

Anti-MMP20 抗体

Anti-MMP20 antibody

5

(1 Review)

|

(2 Publications)

Rabbit Polyclonal MMP20 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MMP20.

別名を表示する

Matrix metalloproteinase-20, MMP-20, Enamel metalloproteinase, Enamelysin, MMP20

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP20 antibody (AB198815)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP20 antibody (AB198815)

Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling MMP20 with ab198815 at 1/40 dilution.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human MMP20. The exact immunogen used to generate this antibody is proprietary information.

O60882

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代替製品

Primary Antibodies

AB76109

Anti-MMP20 antibody [EP1275Y]

RabMAb|Recombinant

Western blot - Anti-MMP20 antibody [EP1275Y] (AB76109)

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組合せ製品

Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

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Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

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  • 19
Primary Antibodies

AB76541

Anti-CDX2 antibody [EPR2764Y]

RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDX2 antibody [EPR2764Y] (AB76541)

  • 4
  • 17
Primary Antibodies

AB115777

Anti-beta Actin antibody [SP124] - Cytoskeleton Marker

20ul selling size|RabMAb|Lab Essentials|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Actin antibody [SP124] - Cytoskeleton Marker (AB115777)

  • 4
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MMP20 also known as Enamelysin is a member of the matrix metalloproteinase (MMP) family. This enzyme has a molecular mass of approximately 54 kDa. MMP20 is mainly expressed in the dental enamel but researchers have also observed its expression in other tissues like the epithelial and mesenchymal cells of the developing tooth. The enzyme plays a role in the breakdown of extracellular matrix components specifically during the formation of tooth enamel where it processes the nascent enamel matrix proteins.
Biological function summary

MMP20 participates in enamel development and maturation. This enzyme cleaves amelogenin an important protein in the enamel matrix to aid in proper enamel mineralization. MMP20 does not function alone; it exists as part of the complex processes necessary for the tooth structure formation. By regulating protein processing MMP20 ensures the replacement of organic matrix with inorganic mineral important for the hardness of enamel.

Pathways

The involvement of MMP20 is critical in the enamel mineralization pathway and intralays network of amelogenesis. It connects with other proteins like ameloblastin and enamelin which collaborate in enamel formation. MMP20 affects these pathways by enabling the proteolytic processing of enamel-specific proteins supporting the structural changes and mineral deposition essential for hard enamel formation.

The role of MMP20 appears significant in amelogenesis imperfecta a genetic condition that affects enamel formation. Mutations within MMP20 can lead to defects in enamel structure causing increased susceptibility to tooth decay and damage. Furthermore MMP20 interacts with other proteins involved in enamel anomalies like amelogenin aggrevating the condition's manifestations when dysfunction occurs.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix : aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
See full target information MMP20
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 14:1100714 PubMed36935757

2023

Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice.

Applications

Unspecified application

Species

Unspecified reactive species

Raed Said,Helyasadat Mortazavi,David Cooper,Katie Ovens,Ian McQuillan,Silvana Papagerakis,Petros Papagerakis

Scientific reports 9:11677 PubMed31406154

2019

Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome.

Applications

Unspecified application

Species

Unspecified reactive species

Shujie Wang,Jia Jia,Dongyan Liu,Meng Wang,Zhen Wang,Xueling Li,Hongzhi Wang,Yong Rui,Zhirong Liu,Wei Guo,Jinfu Nie,Haiming Dai
View all publications
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Abcam product promise

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