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リコンビナントRabMAb

Anti-MLC1 抗体 [EPR10942(2)] - N-terminal (ab186436)

Submit a review Submit a question References (1)
Western blot - Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
  • Western blot - Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
  • Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR10942(2)] to MLC1 - N-terminal
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-MLC1 antibody [EPR10942(2)] - N-terminal
    MLC1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR10942(2)] to MLC1 - N-terminal

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • Human hypothalamus and hippocampus lysates.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

製品の特性

  • 製品の状態

    Liquid

  • 保存方法

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • バッファー

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...

  • 精製度

    Protein A purified

  • ポリ/モノ

    モノクローナル

  • クローン名

    EPR10942(2)

  • アイソタイプ

    IgG

  • 研究分野

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab186436の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
1/1000 - 1/10000. Detects a band of approximately 32 kDa (predicted molecular weight: 41 kDa).
特記事項
WB
1/1000 - 1/10000. Detects a band of approximately 32 kDa (predicted molecular weight: 41 kDa).

ターゲット情報

  • 機能

    Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.

  • 組織特異性

    Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus.

  • 関連疾患

    Leukoencephalopathy, megalencephalic, with subcortical cysts, 1

  • 細胞内局在

    Membrane. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • Information by UniProt

  • 参照データベース

    • 別名

      • KIAA0027 antibody
      • LVM antibody
      • Megalencephalic leukoencephalopathy with subcortical cysts 1 antibody
      • Membrane protein MLC1 antibody
      • MLC antibody
      • MLC1 antibody
      • MLC1_HUMAN antibody
      • VL antibody
      • WKL1 antibody
      see all

    画像

    • Western blot - Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
      Western blot - Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
      Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436) at 1/10000 dilution + Human hypothalamus lysate at 20 µg

      Secondary
      Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

      Predicted band size: 41 kDa



      The observed MW is lower than the predicted 41kDa, which may be due to the high hydrophobicity of the protein.

    • Western blot - Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
      Western blot - Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
      Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436) at 1/1000 dilution + Human hippocampus lysate at 10 µg

      Secondary
      Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

      Predicted band size: 41 kDa



      The observed MW is lower than the predicted 41kDa, which may be due to the high hydrophobicity of the protein.

    • Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)
      Anti-MLC1 antibody [EPR10942(2)] - N-terminal (ab186436)

    参考文献 (1)

    ab186436 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab186436 は 1 報の論文で使用されています。

    • Simon MJ  et al. Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology. Sci Rep 8:12389 (2018). PubMed: 30120299

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