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AB217347

Anti-MKP-1 抗体

Anti-MKP-1 antibody

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(2 Publications)

Rabbit Polyclonal MKP-1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DUSP1 aa 150-250 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

CL100, MKP1, PTPN10, VH1, DUSP1, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, Protein-tyrosine phosphatase CL100, MAP kinase phosphatase 1, MKP-1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKP-1 antibody (AB217347)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKP-1 antibody (AB217347)

Immunohistochemical analysis of formalin-fixed paraffin-embedded mouse lymphoma tissue sections labeling MKP-1 with ab217347 at a 1/200 dilution. DAB staining.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human DUSP1 aa 150-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P28562

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代替製品

Primary Antibodies

AB61201

Anti-MKP-1 antibody

Immunohistochemistry paraffin embedded sections - Anti-MKP-1 antibody (AB61201)

  • 0
  • 0
Primary Antibodies

AB1351

Anti-MKP-1 antibody

Western blot - Anti-MKP-1 antibody (AB1351)

  • 4
  • 6
Primary Antibodies

AB236501

Anti-MKP-1 antibody [OTI4F10]

  • 0
  • 0
Primary Antibodies

AB63548

Anti-MKP-1 (phospho S359) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MKP-1 (phospho S359) antibody (AB63548)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB76310

Anti-DUSP6 antibody [EPR129Y]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-DUSP6 antibody [EPR129Y] (AB76310)

  • 5
  • 16
Primary Antibodies

AB32537

Anti-ERK1 antibody [Y72]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-ERK1 antibody [Y72] (AB32537)

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  • 4
Primary Antibodies

AB200708

Anti-DUSP5 antibody [EPR19684]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-DUSP5 antibody [EPR19684] (AB200708)

  • 5
  • 1
Primary Antibodies

AB307134

Alexa Fluor® 488 Anti-CD3 antibody [SP162]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD3 antibody [SP162] (AB307134)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as MKP-1 also called DUSP1 is a dual-specificity phosphatase. It acts mechanically by dephosphorylating the phospho-tyrosine and phospho-serine/threonine residues of its target proteins. The protein has a molecular weight of about 39 kDa. MKP-1 is ubiquitously expressed but shows higher levels in specific tissues such as liver lung and brain where it regulates various cellular processes.
Biological function summary

MKP-1 influences cellular responses to stress and inflammation by inactivating mitogen-activated protein kinases (MAPKs). It does not exist as part of a permanent complex but temporarily interacts with MAPKs. By dephosphorylating these kinases MKP-1 modulates gene expression cell proliferation and apoptosis. Through these interactions the protein plays a significant role in protecting cells from excessive inflammatory signals and stress-induced damage.

Pathways

The MKP-1 protein is integral to the MAPK signaling pathway and the JNK signaling cascade. MKP-1 directly affects the balance of MAPK-related proteins such as ERK JNK and p38 to help regulate various cellular outcomes. By dephosphorylating these proteins MKP-1 acts as a negative feedback regulator ensuring that cellular responses to external stimuli are controlled and do not become harmful.

MKP-1 is associated with inflammatory diseases and cancer. Inflammatory disorders such as rheumatoid arthritis show link with aberrant regulation of MKP-1 as it often interacts with MAPKs involved in inflammation. In cancer altered MKP-1 expression can affect tumor growth and progression due to its regulatory role on cell proliferation pathways. The protein's interaction with key signaling molecules in these diseases highlights its potential as a therapeutic target.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
See full target information DUSP1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1629676 PubMed40995365

2025

Large extracellular vesicles derived from LPS-preconditioned cardiomyocytes alleviate myocarditis via mediating macrophage polarization and modulating p38 MAPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yanjie Jiang,Yingnan You,Yaxue Xie,Shan Zhou,Mengjie Ma,Bo Han

Cellular and molecular life sciences : CMLS 80:213 PubMed37464072

2023

DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Zhu,Jin Wang,Ting Xin,Shanshan Chen,Ruiying Hu,Yukun Li,Mingming Zhang,Hao Zhou
View all publications
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