AB109420

Anti-MEF2A 抗体 [EPR1451]

Anti-MEF2A antibody [EPR1451]

RabMAb
Recombinant
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(9 Publications)

Rabbit Recombinant Monoclonal MEF2A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications.

別名を表示する

MEF2, MEF2A, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

2 Images

Unknown

Western blot - Anti-MEF2A antibody [EPR1451] (AB109420)

All lanes:

Western blot - Anti-MEF2A antibody [EPR1451] (ab109420) at 1/10000 dilution

Lane 1:

Human heart lysate at 10 µg

Lane 2:

Human skeletal muscle lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Lane 4:

Saos-2 cell lysate at 10 µg

Predicted band size: 55 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

ab109420, at 1/100 dilution, staining MEF2A in HeLa cells by Immunohistochemistry.

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR1451

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MEF2A or Myocyte Enhancer Factor 2A is a transcription factor involved in regulating gene expression. MEF2A is approximately 55 kDa in size and is expressed in a variety of tissues including muscle brain and heart. It is part of the MEF2 family of transcription factors which all share a similar MADS-box/MEF2 domain structure. MEF2A binds to DNA and influences the transcription of genes involved in muscle differentiation and development.

Biological function summary

MEF2A participates in transcriptional regulation as part of a larger complex that includes other regulatory proteins. This transcription factor plays an essential role in the development and function of muscles. It activates the transcription of genes necessary for muscle fiber formation and adaptation. MEF2A also influences the expression of genes related to neuronal survival and plasticity impacting cognitive function and memory in the brain.

Pathways

MEF2A is involved in both the MAPK/ERK and PI3K/Akt pathways which are significant for cellular growth survival and differentiation. MEF2A interacts with proteins like MAPK and PI3K impacting these signaling pathways that regulate cell proliferation and apoptosis. This interaction highlights its role in cellular response to external stimuli and stress signals positioning MEF2A as an important factor in cell fate decisions.

Mutations or dysregulation of MEF2A are connected to cardiovascular diseases particularly coronary artery disease. MEF2A mutations can disrupt normal transcriptional regulation leading to impaired cardiovascular function. Additionally alterations in MEF2A function are linked to neurodegenerative disorders such as Alzheimer's disease where it may interact with proteins including Tau and amyloid precursor protein influencing neuronal health and survival.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

See full target information MEF2A

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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 13: PubMed39857778

2025

Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Charmy Twala,Sibusiso Malindisa,Chamone Munnik,Selisha Sooklal,Monde Ntwasa

Frontiers in bioengineering and biotechnology 10:1022830 PubMed36304901

2022

Hsa_circ_0008870 suppresses bone formation of growth plate through inhibition of miR-185-3p/ MAPK1 axis in idiopathic short stature.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwen Wu,Jinghong Yuan,Jiantian Li,Zhi Du,Ming Yin,Xigao Cheng,Xijuan Liu,Jingyu Jia

Frontiers in cell and developmental biology 9:671857 PubMed34490239

2021

Lnc-GD2H Promotes Proliferation by Forming a Feedback Loop With c-Myc and Enhances Differentiation Through Interacting With NACA to Upregulate Myog in C2C12 Myoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Chen,Si Lei,Yanling She,Shanyao Zhou,Huacai Shi,Cheng Li,Ting Jiang

Frontiers in physiology 12:659272 PubMed34305633

2021

Knockdown of CNN3 Impairs Myoblast Proliferation, Differentiation, and Protein Synthesis via the mTOR Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yanling She,Cheng Li,Ting Jiang,Si Lei,Shanyao Zhou,Huacai Shi,Rui Chen

Nature communications 10:3276 PubMed31332177

2019

Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart.

Applications

Unspecified application

Species

Unspecified reactive species

Sophie Payne,Mala Gunadasa-Rohling,Alice Neal,Andia N Redpath,Jyoti Patel,Kira M Chouliaras,Indrika Ratnayaka,Nicola Smart,Sarah De Val

The Journal of neuroscience : the official journal 39:5064-5079 PubMed31015341

2019

Antagonizing Increased Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.

Applications

Unspecified application

Species

Unspecified reactive species

Vamshidhar R Vangoor,Cristina R Reschke,Ketharini Senthilkumar,Lieke L van de Haar,Marina de Wit,Giuliano Giuliani,Mark H Broekhoven,Gareth Morris,Tobias Engel,Gary P Brennan,Ronan M Conroy,Peter C van Rijen,Peter H Gosselaar,Stephanie Schorge,Roel Q J Schaapveld,David C Henshall,Pierre N E De Graan,R Jeroen Pasterkamp

Biochemical and biophysical research communication 500:645-649 PubMed29678571

2018

The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Bangfu Zhu,Ruth E Carmichael,Luis Solabre Valois,Kevin A Wilkinson,Jeremy M Henley

Scientific reports 8:5263 PubMed29588465

2018

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Applications

Unspecified application

Species

Unspecified reactive species

Ruth E Carmichael,Kevin A Wilkinson,Tim J Craig,Michael C Ashby,Jeremy M Henley

Genes & development 30:2297-2309 PubMed27898394

2016

MEF2 transcription factors are key regulators of sprouting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Sacilotto,Kira M Chouliaras,Leonid L Nikitenko,Yao Wei Lu,Martin Fritzsche,Marsha D Wallace,Svanhild Nornes,Fernando García-Moreno,Sophie Payne,Esther Bridges,Ke Liu,Daniel Biggs,Indrika Ratnayaka,Shane P Herbert,Zoltán Molnár,Adrian L Harris,Benjamin Davies,Gareth L Bond,George Bou-Gharios,John J Schwarz,Sarah De Val

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MEF2A 抗体 [EPR1451]

Anti-MEF2A antibody [EPR1451]

Western blot - Anti-MEF2A antibody [EPR1451] (AB109420)

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (9)

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Abcam product promise