AB181494

Anti-MEF2A 抗体 [2F9H2]

Name: Anti-MEF2A 抗体 [2F9H2] (ab181494) | Abcam
Brand: Abcam Limited
SKU: AB181494
Price: 73000 JPY
Availability: InStock

Anti-MEF2A antibody [2F9H2]

Be the first to review this product! Submit a review

(3 Publications)

Mouse Monoclonal MEF2A antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEF2A aa 350 to C-terminus.

別名を表示する

MEF2, MEF2A, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

2 Images

Supplier Data

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

Expected MWt is 38 kDa.

All lanes:

Western blot - Anti-MEF2A antibody [2F9H2] (ab181494) at 1/500 dilution

All lanes:

MEF2A (AA: 391-497) recombinant protein

Predicted band size: 55 kDa

false

Supplier Data

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

All lanes:

Western blot - Anti-MEF2A antibody [2F9H2] (ab181494) at 1/500 dilution

Lane 1:

HEK293 cell lysate

Lane 2:

MEF2A (AA: 391-497)-hIgGFc transfected HEK293 cell lysate

Predicted band size: 55 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

2F9H2

アイソタイプ

IgG1

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Recombinant Fragment Protein within Human MEF2A aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q02078

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

Purified from tissue culture supernatant.

バッファー組成

Preservative: 0.05% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MEF2A or Myocyte Enhancer Factor 2A is a transcription factor involved in regulating gene expression. MEF2A is approximately 55 kDa in size and is expressed in a variety of tissues including muscle brain and heart. It is part of the MEF2 family of transcription factors which all share a similar MADS-box/MEF2 domain structure. MEF2A binds to DNA and influences the transcription of genes involved in muscle differentiation and development.

Biological function summary

MEF2A participates in transcriptional regulation as part of a larger complex that includes other regulatory proteins. This transcription factor plays an essential role in the development and function of muscles. It activates the transcription of genes necessary for muscle fiber formation and adaptation. MEF2A also influences the expression of genes related to neuronal survival and plasticity impacting cognitive function and memory in the brain.

Pathways

MEF2A is involved in both the MAPK/ERK and PI3K/Akt pathways which are significant for cellular growth survival and differentiation. MEF2A interacts with proteins like MAPK and PI3K impacting these signaling pathways that regulate cell proliferation and apoptosis. This interaction highlights its role in cellular response to external stimuli and stress signals positioning MEF2A as an important factor in cell fate decisions.

Mutations or dysregulation of MEF2A are connected to cardiovascular diseases particularly coronary artery disease. MEF2A mutations can disrupt normal transcriptional regulation leading to impaired cardiovascular function. Additionally alterations in MEF2A function are linked to neurodegenerative disorders such as Alzheimer's disease where it may interact with proteins including Tau and amyloid precursor protein influencing neuronal health and survival.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

See full target information MEF2A

style

left-column

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:17364 PubMed40389489

2025

Inhibitory effects of high extracellular L-glutamate concentrations on skeletal myogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Himiko Ban,Koji Nobe,Soushi Kobayashi

Amino acids 51:1657-1666 PubMed31729551

2019

Methionine restriction at the post-weanling period promotes muscle fiber transition in piglets and improves intramuscular fat content in growing-finishing pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wu,Haiwen Zhang,Lin Na,Xihong Zhou,Xiang Li,Yurong Zhao,Zhen Wen,Qinghua He

Endocrinology 156:1303-15 PubMed25646713

2015

Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Wagner L Reis,Chun-Xia Yi,Yuanqing Gao,Mathias H Tschöp,Javier E Stern

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MEF2A 抗体 [2F9H2]

Anti-MEF2A antibody [2F9H2]

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise