AB8101

Anti-MCP1 抗体 [ECE.2]

Name: Anti-MCP1 抗体 [ECE.2] (ab8101) | Abcam
Brand: Abcam Limited
SKU: AB8101
Price: 76000 JPY
Availability: InStock
Rating: 4 (1 reviews)

Anti-MCP1 antibody [ECE.2]

(1 Review)

(34 Publications)

Rat Monoclonal MCP1 antibody. Suitable for IHC-Fr and reacts with Mouse samples. Cited in 34 publications.

別名を表示する

Je, Mcp1, Scya2, Ccl2, C-C motif chemokine 2, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, Platelet-derived growth factor-inducible protein JE, Small-inducible cytokine A2, MCP-1

1 Images

Immunohistochemistry (Frozen sections) - Anti-MCP1 antibody [ECE.2] (AB8101)

IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-MCP1 antibody [ECE.2] (AB8101)

Detection of MCP-1 in mouse testis. ab8101 has been used in a 10x dilution, the magnification was 200x.

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

ECE.2

アイソタイプ

IgG1

キャリアフリー

交差種

Mouse

アプリケーション

IHC-Fr

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

The antibody reacts with murine JE / MCP-1.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

0.2 µm filtered antibody solution

バッファー組成

Preservative: 0.02% Sodium azide Constituents: PBS, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MCP-1 also known as CCL2 is a chemokine involved in the recruitment of monocytes to sites of injury and inflammation. This protein consists of 76 amino acids and has a molecular weight of about 11 kDa. MCP-1 is expressed in a wide range of cell types including endothelial cells fibroblasts and monocytes. It acts by binding to the chemokine receptor CCR2 stimulating intracellular signaling pathways that mediate cell migration.

Biological function summary

The role of MCP-1 is significant in guiding immune cells to areas requiring immune response. It does not form part of a complex but operates as a singular entity to affect immune signaling. MCP-1 influences the behavior of monocytes and macrophages by inducing chemotaxis and activating their effector functions. Through this mechanism it aids in the inflammatory response and tissue repair.

Pathways

MCP-1 participates in the inflammatory pathways by cooperating with key proteins like CCR2. It facilitates the JAK-STAT signaling pathway which is vital for transmitting extracellular information into cellular responses. The interaction of MCP-1 with CCR2 influences the activation of downstream proteins like STAT3 enabling various immune responses. MCP-1 thereby plays a central role in modulating inflammation-related pathways.

MCP-1 has a connection to inflammatory bowel disease and atherosclerosis. In such conditions elevated levels of MCP-1 can exacerbate inflammatory responses by recruiting monocytes to dysfunctional sites worsening tissue damage. Through its interaction with CCR2 MCP-1 becomes a pivotal factor in chronic inflammation. Targeting this MCP-1/CCR2 axis can provide therapeutic opportunities for modulating disease progression in these inflammatory diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed : 29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed : 29993042).

See full target information Ccl2

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文献 (34)

Recent publications for all applications. Explore the full list and refine your search

Environmental toxicology 39:1175-1186 PubMed37860912

2023

Airborne magnetite nanoparticles induced early vascular pathologies by disrupting lipid metabolism under high-fat dietary patterns.

Applications

Unspecified application

Species

Unspecified reactive species

Jingxu Zhang,Hongyan Yu,Ruonan Pan,Gan Miao,Yu Wang,Ziyuan Li,Haiyi Yu,Lin Lu,Xiaoting Jin

Acta pharmaceutica Sinica. B 13:632-647 PubMed36873191

2023

Anti-PD-L1 antibody enhances curative effect of cryoablation antibody-dependent cell-mediated cytotoxicity mediating PD-L1CD11b cells elimination in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jizhou Tan,Ting Liu,Wenzhe Fan,Jialiang Wei,Bowen Zhu,Yafang Liu,Lingwei Liu,Xiaokai Zhang,Songling Chen,Haibiao Lin,Yuanqing Zhang,Jiaping Li

Cell death & disease 13:562 PubMed35732633

2022

LncRNA IRAR regulates chemokines production in tubular epithelial cells thus promoting kidney ischemia-reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Jia,Sujuan Xu,Ting Ren,Tianyi Pan,Xiaoyan Wang,Yunlu Zhang,Zhouping Zou,Man Guo,Qi Zeng,Bo Shen,Xiaoqiang Ding

Molecular therapy : the journal of the American Society of Gene Therapy 30:2760-2784 PubMed35477657

2022

Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Chiara Trolese,Carlotta Scarpa,Valentina Melfi,Paola Fabbrizio,Francesca Sironi,Martina Rossi,Caterina Bendotti,Giovanni Nardo

Cell death & disease 13:158 PubMed35177591

2022

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zihang Ling,Wei Li,Jiaqi Hu,Yuanyuan Li,Miao Deng,Siyuan Zhang,Xianyue Ren,Tong Wu,Juan Xia,Bin Cheng,Xiaoan Tao

Journal of advanced research 41:39-48 PubMed36328752

2022

DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Rongjun Zou,Jun Tao,Junxiong Qiu,Huimin Lu,Jianhua Wu,Hang Zhu,Ruibing Li,David Mui,Sam Toan,Xing Chang,Hao Zhou,Xiaoping Fan

Cell death & disease 12:882 PubMed34580284

2021

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Tu,Jin Gong,Zhenzhen Zhou,Dean Tian,Zhijun Wang

JCI insight 6: PubMed34369383

2021

Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Jiafa Ren,Yuemei Xu,Xiaohan Lu,Liming Wang,Shintaro Ide,Gentzon Hall,Tomokazu Souma,Jamie R Privratsky,Robert F Spurney,Steven D Crowley

Aging 13:10659-10671 PubMed33770763

2021

Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wanli Zhang,Huan Yu,Qingxia Lin,Xiaoqian Liu,Yifan Cheng,Binbin Deng

Theranostics 11:506-521 PubMed33391489

2021

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Tong,Hui Hui,Wenting Shang,Yingqian Zhang,Feng Tian,Qiang Ma,Xin Yang,Jie Tian,Yundai Chen

View all publications

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