Anti-MCP1 抗体 (ab9899)
Key features and details
- Rabbit polyclonal to MCP1
- Suitable for: Sandwich ELISA
- Isotype: unknown
製品の概要
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製品名
Anti-MCP1 antibody
MCP1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to MCP1 -
由来種
Rabbit -
アプリケーション
適用あり: Sandwich ELISAmore details -
免疫原
Recombinant fragment corresponding to Mouse MCP1 aa 1 to the C-terminus.
Database link: P10148 -
特記事項
JE, also known as monocyte chemotactic protein (MCP-1), plays an important role in the inflammatory response of blood monocytes and tissue macrophages
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized:Reconstitute with 200µl of sterile water. -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
No preservative, sterile filtered -
Concentration information loading... -
精製度
Immunogen affinity purified -
一次抗体 備考
JE, also known as monocyte chemotactic protein (MCP-1), plays an important role in the inflammatory response of blood monocytes and tissue macrophages -
ポリ/モノ
ポリクローナル -
アイソタイプ
unknown -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab9899の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Sandwich ELISA |
Use at an assay dependent concentration.
To detect MCP-1 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech’s Biotinylated Anti-Murine MCP-1 (500-P113Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant MCP-1. |
| 特記事項 |
|---|
|
Sandwich ELISA
Use at an assay dependent concentration. To detect MCP-1 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech’s Biotinylated Anti-Murine MCP-1 (500-P113Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant MCP-1. |
ターゲット情報
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機能
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. -
配列類似性
Belongs to the intercrine beta (chemokine CC) family. -
翻訳後修飾
Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. -
細胞内局在
Secreted. - Information by UniProt
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別名
- C-C motif chemokine 2 antibody
- CCL2 antibody
- CCL2_HUMAN antibody
see all
画像
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Sandwich ELISA - Anti-MCP1 antibody (ab9899)
ab9899 detecting MCP1 by sandwich ELISA.
データシートおよび資料
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Datasheet download
参考文献 (6)
ab9899 は 6 報の論文で使用されています。
- Shi X et al. Cellular distribution of C-C motif chemokine ligand 2 like immunoreactivities in frontal cortex and corpus callosum of normal and lipopolysaccharide treated animal. BMC Neurosci 23:20 (2022). PubMed: 35354428
- Xu SB et al. Peptide 17 alleviates early hypertensive renal injury by regulating the Hippo/YAP signalling pathway. Nephrology (Carlton) 27:712-723 (2022). PubMed: 35608936
- Huang T et al. Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer. Front Oncol 10:19 (2020). PubMed: 32064233
- Feng Y et al. Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease. Cell Death Dis 11:513 (2020). PubMed: 32641688
- Lv J et al. Amygdalin ameliorates the progression of atherosclerosis in LDL receptor-deficient mice. Mol Med Rep 16:8171-8179 (2017). PubMed: 28983592
- Zhang L et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527:100-104 (2015). PubMed: 26479035
