AB23458

Anti-Mannan Binding Lectin/MBL 抗体 [1E2]

Name: Anti-Mannan Binding Lectin/MBL 抗体 [1E2] (ab23458) | Abcam
Brand: Abcam Limited
SKU: AB23458
Price: 73000 JPY
Availability: InStock

Anti-Mannan Binding Lectin/MBL antibody [1E2]

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(4 Publications)

Mouse Monoclonal Mannan Binding Lectin/MBL antibody. Suitable for ELISA, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Full Length Protein corresponding to Human MBL2.

別名を表示する

COLEC1, MBL, MBL2, Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

1E2

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

交差種

Human

アプリケーション

ELISA, WB

applications

免疫原

Full Length Protein corresponding to Human MBL2. The exact immunogen used to generate this antibody is proprietary information.

P11226

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/10000", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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製品の詳細

ab23458 reacts with human MBL both in its poltmeric conforation and as a single subunit of moleculat mass 26 kDa. Can be applied for quantitative measurement of MBL in plasma or serum.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Mannan Binding Lectin often referred to as MBL is an important player in the innate immune system. It is known alternatively as mannose-binding lectin or mannan-binding protein. The mass of MBL is approximately 32 to 34 kilodaltons and it is primarily produced in the liver. MBL circulates in the bloodstream where it can recognize patterns on the surface of pathogens such as bacteria and viruses through its lectin-binding domain. This recognition leads to the activation of other components that play roles in immune response.

Biological function summary

Mannan Binding Lectin serves a significant role in immune defense by binding to carbohydrate structures on pathogens. It is part of a complex known as the lectin pathway of the complement system one of three pathways that activate the complement system to enhance pathogen removal. MBL can activate through a series of proteases leading to opsonization cell lysis and inflammation which are vital responses to infection.

Pathways

Mannan recognition by MBL initiates the lectin pathway an essential component of the complement system. This pathway converges with the classical and alternative pathways to enhance the immune response. MBL works closely with MBL-associated serine proteases (MASPs) particularly MASP-1 and MASP-2 which cleave complement proteins resulting in pathogen opsonization and membrane attack complex formation. These actions are tightly regulated and ensure effective defense against invaders.

Deficiencies or polymorphisms in MBL can lead to increased susceptibility to infections and developmental complications of the immune system. Individuals with low MBL levels may experience recurrent respiratory infections or other bacterial infections due to inadequate complement activation. Moreover variations in the MBL protein have connections with autoimmune diseases such as systemic lupus erythematosus where MBL levels might influence disease severity. In these conditions altered interactions with other immune proteins like C4 and C3 may contribute to pathological responses.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Calcium-dependent lectin involved in innate immune defense (PubMed : 35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed : 35102342).

See full target information MBL2

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Stem cells international 2021:1530445 PubMed34691188

2021

Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1.

Applications

Unspecified application

Species

Unspecified reactive species

Chun Liu,Jianhua Xue,Bo Xu,Aixian Zhang,Lili Qin,Jiajia Liu,Yang Yang

Clinical and experimental immunology 144:512-20 PubMed16734621

2006

Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions.

Applications

Unspecified application

Species

Unspecified reactive species

M Harboe,P Garred,M S Borgen,G L Stahl,A Roos,T E Mollnes

Immunology 109:360-4 PubMed12807481

2003

Immature dendritic cells possess a sugar-sensitive receptor for human mannan-binding lectin.

Applications

Unspecified application

Species

Unspecified reactive species

Ian Downing,Claus Koch,David C Kilpatrick

Transplantation 75:1204-13 PubMed12717204

2003

Complement activation in early protocol kidney graft biopsies after living-donor transplantation.

Applications

Unspecified application

Species

Unspecified reactive species

Ståle Sund,Torstein Hovig,Anna Varberg Reisaeter,Helge Scott,Øystein Bentdal,Tom Eirik Mollnes

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Mannan Binding Lectin/MBL 抗体 [1E2]

Anti-Mannan Binding Lectin/MBL antibody [1E2]

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

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Abcam product promise