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AB268080

Anti-MAGEA4 抗体 [CPTC-MAGEA4-1]

Anti-MAGEA4 antibody [CPTC-MAGEA4-1]

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(3 Publications)

Mouse Monoclonal MAGEA4 antibody. Suitable for Protein Array, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MAGEA4.

別名を表示する

MAGE4, MAGEA4, Melanoma-associated antigen 4, Cancer/testis antigen 1.4, MAGE-4 antigen, MAGE-41 antigen, MAGE-X2 antigen, CT1.4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA4 antibody [CPTC-MAGEA4-1] (AB268080)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA4 antibody [CPTC-MAGEA4-1] (AB268080)

Formalin-fixed, paraffin-embedded human testis tissue stained for MAGEA4 using ab268080 at 2 μg/ml in immunohistochemical analysis.

Protein Array - Anti-MAGEA4 antibody [CPTC-MAGEA4-1] (AB268080)
  • Protein Array

Unknown

Protein Array - Anti-MAGEA4 antibody [CPTC-MAGEA4-1] (AB268080)

Protein Array containing more than 19,000 full-length human proteins using ab268080. Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

CPTC-MAGEA4-1

アイソタイプ

IgG2c

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, Protein Array

applications

免疫原

Recombinant Full Length Protein corresponding to Human MAGEA4.

P43358

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代替製品

Primary Antibodies

AB229011

Anti-MAGEA4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA4 antibody (AB229011)

  • 0
  • 0
Primary Antibodies

AB139297

Anti-MAGEA4 antibody [OTI1F9]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA4 antibody [OTI1F9] (AB139297)

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Primary Antibodies

AB268201

Anti-MAGEA4 antibody [CPTC-MAGEA4-1] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA4 antibody [CPTC-MAGEA4-1] - BSA and Azide free (AB268201)

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組合せ製品

Primary Antibodies

AB219650

Anti-PRAME antibody [EPR20330]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRAME antibody [EPR20330] (AB219650)

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Primary Antibodies

AB209667

Anti-MAGEC2 antibody [EPR19064]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-MAGEC2 antibody [EPR19064] (AB209667)

  • 0
  • 0
Primary Antibodies

AB223162

Anti-MAGE3 antibody [EPR19065]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGE3 antibody [EPR19065] (AB223162)

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Primary Antibodies

AB223498

Anti-CTAG1B antibody [SP349]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTAG1B antibody [SP349] (AB223498)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
精製に関する特記事項
Purified from Bioreactor concentrate
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA4 also known as MAGE-A4 is part of the melanoma-associated antigen family. This protein is encoded by the MAGEA4 gene and is characterized by a molecular mass of approximately 42 kDa. Its expression is limited to certain tissues including the testis and is often silent in normal somatic tissues. However MAGEA4 is frequently found in various types of tumors making it a target of interest for cancer research and therapy.
Biological function summary

MAGEA4 participates in cellular processes related to cancer progression. Although not part of a multi-protein complex its presence in tumorous tissues suggests a role in modulating cellular mechanisms that favor tumor survival and proliferation. MAGEA4 does not directly interact with other proteins but might affect cellular pathways indirectly contributing to oncogenesis.

Pathways

MAGEA4 influences several cellular mechanisms that are related to cancer development. While it is not a central player in major biological pathways its function relates to processes affecting cell cycle regulation and apoptosis. This connection was observed in studies showing interactions with other cancer-related proteins like p53 suggesting that MAGEA4 can modify responses to apoptotic signals and may interact with or affect the TP53 pathway.

MAGEA4 is prominently linked to various cancers including melanomas and carcinomas such as lung cancer. Its frequent expression in tumor cells but not in normal tissues makes MAGEA4 a target for cancer immunotherapy. Additionally studies have shown that MAGEA4 may interfere with the immune system's ability to detect and destroy cancerous cells partly due to interactions with proteins like CTLA-4 further emphasizing its potential as a therapeutic target in oncology.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed : 22842486). Also negatively regulates p53-mediated apoptosis (PubMed : 22842486).
See full target information MAGEA4
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Bioactive materials 9:491-507 PubMed34820585

2021

Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation.

Applications

Unspecified application

Species

Unspecified reactive species

Yijun He,Wenhao Wang,Shaozhang Lin,Yixi Yang,Lizhi Song,Yihan Jing,Lihao Chen,Zaopeng He,Wei Li,Ao Xiong,Kelvin W K Yeung,Qi Zhao,Yuan Jiang,Zijie Li,Guoxian Pei,Zhi-Yong Zhang

Biomedicines 9: PubMed34356903

2021

TGF-β1 Receptor Inhibitor SB525334 Attenuates the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells via the TGF-β1 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jung-Yoon Heo,Jun-Young Do,Yunmee Lho,A-Young Kim,Sang-Woon Kim,Seok-Hui Kang

International journal of molecular sciences 22: PubMed33947038

2021

Effects of TGF-β1 Receptor Inhibitor GW788388 on the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yunmee Lho,Jun-Young Do,Jung-Yoon Heo,A-Young Kim,Sang-Woon Kim,Seok-Hui Kang
View all publications
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Abcam product promise

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