Anti-MAdCAM1 抗体 [314G8]
Anti-MAdCAM1 antibody [314G8]
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(1 Publication)
Mouse Monoclonal MAdCAM1 antibody. Suitable for Flow Cyt, ELISA, WB, IHC-P, FuncS, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Human MADCAM1.
別名を表示する
Mucosal addressin cell adhesion molecule 1, MAdCAM-1, hMAdCAM-1, MADCAM1
Reactivity data
製品の詳細
出荷温度及び保存条件
製品の状態
精製方法
精製に関する特記事項
バッファー組成
出荷温度
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MAdCAM-1 facilitates lymphocyte homing to mucosal tissues. It plays a part in the adhesive interactions between endothelial cells and lymphocytes as a component of the immune surveillance system enabling T cells and B cells to move into areas where they are needed. MAdCAM-1 forms complexes with integrins notably alpha4beta7 which are integral to its adhesion functions. Through its role in guiding lymphocytes it influences immune response and inflammation in mucosal environments.
Pathways
MAdCAM-1 contributes importantly to the trafficking of immune cells. It is involved in the regulation of cell adhesion and migration pathways. The protein interacts extensively with the integrin family especially integrin alpha4beta7 which facilitates lymphocyte entry into the intestinal wall. Additionally it works with chemokine receptors and cytokines that further influence cell movement and homing to specific tissues. This integrative role reinforces its importance in immune response and mucosal immunity.
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ターゲットの情報
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
The American journal of pathology 176:556-62 PubMed20035048
2009
Applications
IHC-Fr
Species
Human
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