AB139190

Anti-LZP 抗体 [EPR9348]

Anti-LZP antibody [EPR9348]

RabMAb
Recombinant
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(2 Publications)

Rabbit Recombinant Monoclonal LZP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

別名を表示する

LZP, UNQ826/PRO1753, OIT3, Oncoprotein-induced transcript 3 protein, Liver-specific zona pellucida domain-containing protein

1 Images

Unknown

Western blot - Anti-LZP antibody [EPR9348] (AB139190)

All lanes:

Western blot - Anti-LZP antibody [EPR9348] (ab139190) at 1/1000 dilution

Lane 1:

Human fetal liver lysate at 10 µg

Lane 2:

Human plasma lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 60 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR9348

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

LZP also known as leucine zipper protein is a structural protein that plays a significant role in various cellular processes. It has a molecular mass of approximately 25 kDa. LZP is expressed highly in the liver and lungs with moderate expression observed in the brain and heart. The presence of the leucine zipper motif in LZP allows it to function as a transcription factor facilitating the regulation of gene expression through dimerization and DNA binding.

Biological function summary

LZP interacts with other proteins to regulate cell proliferation and differentiation. The protein forms part of a larger complex involved in these cellular processes. Through its action in transcription regulation LZP influences the expression of genes critical for cell cycle progression and apoptosis. During normal cellular function LZP maintains a balance between cell growth and programmed cell death contributing to tissue homeostasis.

Pathways

Research identifies LZP playing a role in the MAPK/ERK signaling pathway and the NF-κB signaling pathway. These pathways are essential for transmitting signals from the cell surface to the DNA in the nucleus impacting cell survival and differentiation. LZP interacts closely with proteins such as c-Jun and p53 within these pathways suggesting its importance in signal transduction and gene transcription.

LZP has connections to certain types of cancer including liver and lung cancer. Studies indicate that aberrant expression or mutations in LZP can lead to uncontrolled cell proliferation contributing to tumorigenesis. In addition LZP's interaction with the protein p53 known for its tumor-suppressing activities highlights its role in these diseases. Understanding LZP's functions and pathways offers potential targets for therapeutic intervention in related disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

May be involved in hepatocellular function and development.

See full target information OIT3

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cardiovascular medicine 9:981333 PubMed36818914

2023

Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Kangbo Li,Victoria Kratzmann,Mengjun Dai,Nora Gatzke,Petra Rocic,Peter Bramlage,Olaf Grisk,Lubomir T Lubomirov,Meike Hoffmeister,Martin A Lauxmann,Oliver Ritter,Eva Buschmann,Michael Bader,Anja Bondke Persson,Ivo Buschmann,Philipp Hillmeister

Cancer immunology, immunotherapy : CII 71:2677-2689 PubMed35353239

2022

OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Yang,Jiangang Zhang,Yanquan Xu,Jingchun Wang,Huakan Zhao,Juan Lei,Yu Zhou,Yu Chen,Lei Wu,Mingyue Zhou,Lu Zheng,Xiaohui Ji,Yongsheng Li

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LZP 抗体 [EPR9348]

Anti-LZP antibody [EPR9348]

Western blot - Anti-LZP antibody [EPR9348] (AB139190)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise