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AB122100

Anti-LTV1 抗体

Anti-LTV1 antibody

3

(1 Review)

|

(3 Publications)

Rabbit Polyclonal LTV1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LTV1.

別名を表示する

C6orf93, LTV1, Protein LTV1 homolog

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LTV1 antibody (AB122100)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LTV1 antibody (AB122100)

ab122100, at 1/200, staining LTV1 in paraffin embedded Human placenta tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-LTV1 antibody (AB122100)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LTV1 antibody (AB122100)

ab122100, at 4 µg/ml, staining LTV1 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).

Western blot - Anti-LTV1 antibody (AB122100)
  • WB

Unknown

Western blot - Anti-LTV1 antibody (AB122100)

All lanes:

Western blot - Anti-LTV1 antibody (ab122100) at 1/250 dilution

Lane 1:

RT 4 cell line lysate

Lane 2:

U 251 MG cell line lysate

Lane 3:

Human plasma

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 55 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human LTV1. The exact immunogen used to generate this antibody is proprietary information.

Q96GA3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

LTV1 is a protein that functions in the assembly of ribosomal small subunits. It is also known as LTV1 homolog and has a molecular mass of approximately 50 kilodaltons. This protein is expressed in the cytoplasm and associated with the pre-40S ribosomal subunit. LTV1 plays a pivotal role in ribosome biogenesis specifically in the maturation and transport of the 40S subunit from the nucleus to the cytoplasm.
Biological function summary

LTV1 facilitates the late stages of ribosome assembly. It is an integral component of the ribosomal RNA processing machinery and associates with several other ribosomal proteins and processing factors forming part of the preribosomal complex. LTV1 is essential for the release of assembly factors and processing of the 18S rRNA which are critical steps in producing functional ribosomes necessary for effective protein synthesis.

Pathways

LTV1 participates in ribosome biogenesis and nucleocytoplasmic transport pathways. It interacts with other assembly factors such as RIOK2 and TSR1 to ensure the proper maturation of the 40S ribosomal subunit. These interactions and processes are vital for the downstream translation initiation pathway which influences overall protein production within the cell and cellular growth.

LTV1 links to cancer and ribosomopathy. Disruptions in ribosome biogenesis where LTV1 plays a part can lead to uncontrolled cell growth characteristic of cancer. Additionally mutations or misregulation in LTV1 can contribute to ribosomopathies disorders caused by defects in ribosomal functions. In these conditions LTV1 interacts with proteins implicated in cell cycle control and stress response pathways such as C-MYC which further illustrates its role in connecting ribosome function to disease states.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Essential for ribosome biogenesis.
See full target information LTV1
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 31:1970-1978 PubMed34999892

2022

Mutations in the ribosome biogenesis factor gene LTV1 are linked to LIPHAK syndrome, a novel poikiloderma-like disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hoon Han,Gavin Ryan,Alyson Guy,Lu Liu,Mathieu Quinodoz,Ingrid Helbling,Joey E Lai-Cheong,Julian Barwell,Marc Folcher,John A McGrath,Celia Moss,Carlo Rivolta

Nucleic acids research 48:12900-12916 PubMed33245768

2020

PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).

Applications

Unspecified application

Species

Unspecified reactive species

Anne-Marie Landry-Voyer,Danny Bergeron,Carlo Yague-Sanz,Breac Baker,Francois Bachand

Molecular and cellular biology 36:3019-3032 PubMed27697862

2016

Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.

Applications

Unspecified application

Species

Unspecified reactive species

Anne-Marie Landry-Voyer,Sarah Bilodeau,Danny Bergeron,Kiersten L Dionne,Sarah A Port,Caroline Rouleau,François-Michel Boisvert,Ralph H Kehlenbach,François Bachand
View all publications
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