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リコンビナントRabMAb

Anti-LNK 抗体 [EPR7342] (ab154848)

Reviews (1) Submit a question References (1)
Western blot - Anti-LNK antibody [EPR7342] (ab154848)
  • Anti-LNK antibody [EPR7342] (ab154848)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR7342] to LNK
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-LNK antibody [EPR7342]
    LNK 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR7342] to LNK

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details
    適用なし: Flow Cyt,ICC/IF,IHC-P or IP

  • 種交差性

    交差種: Human

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • Ramos, MOLT4 and Raji cell lysates.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab154848の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB (1)
1/1000 - 1/10000. Predicted molecular weight: 63 kDa.
特記事項
WB
1/1000 - 1/10000. Predicted molecular weight: 63 kDa.
追加情報
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

ターゲット情報

  • 機能

    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

  • 組織特異性

    Preferentially expressed by lymphoid cell lines.

  • 関連疾患

    Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
    Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.

  • 配列類似性

    Belongs to the SH2B adapter family.
    Contains 1 PH domain.
    Contains 1 SH2 domain.

  • 翻訳後修飾

    Tyrosine phosphorylated by LCK.
  • Information by UniProt

  • 参照データベース

    • 別名

      • IDDM20 antibody
      • Lymphocyte adapter protein antibody
      • Lymphocyte specific adapter protein antibody
      • Lymphocyte specific adapter protein Lnk antibody
      • Lymphocyte-specific adapter protein Lnk antibody
      • SH2B adapter protein 3 antibody
      • SH2B adaptor protein 3 antibody
      • Sh2b3 antibody
      • SH2B3_HUMAN antibody
      • Signal transduction protein Lnk antibody
      see all

    画像

    • Western blot - Anti-LNK antibody [EPR7342] (ab154848)
      Western blot - Anti-LNK antibody [EPR7342] (ab154848)
      All lanes : Anti-LNK antibody [EPR7342] (ab154848) at 1/1000 dilution

      Lane 1 : Ramos cell lysate
      Lane 2 : MOLT4 cell lysate
      Lane 3 : Raji cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 63 kDa

    • Anti-LNK antibody [EPR7342] (ab154848)
      Anti-LNK antibody [EPR7342] (ab154848)

    参考文献 (1)

    ab154848 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab154848 は 1 報の論文で使用されています。

    • Cai S  et al. SH2B3, Transcribed by STAT1, Promotes Glioblastoma Progression Through Transducing IL-6/gp130 Signaling to Activate STAT3 Signaling. Front Cell Dev Biol 9:606527 (2021). PubMed: 33937225

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    Western blot abreview for Anti-LNK antibody [EPR7342]

     Good
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Human Cell lysate - whole cell (iPSC derived blood cell)
    Gel Running Conditions
    Reduced Denaturing
    Loading amount
    100 µg
    Specification
    iPSC derived blood cell
    Blocking step
    Milk as blocking agent for 3 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    投稿 Jul 19 2016

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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