Anti-LMBRD1 抗体 (ab105419)
Key features and details
- Rabbit polyclonal to LMBRD1
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-LMBRD1 antibody -
製品の詳細
Rabbit polyclonal to LMBRD1 -
由来種
Rabbit -
特異性
LMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members. -
アプリケーション
適用あり: ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
An 18 amino acid peptide from the C-terminus of Human LMBRD1 (NP_060838)
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ポジティブ･コントロール
- Human Brain Tissue Lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab105419の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
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| IHC-P |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
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ICC/IF
Use a concentration of 20 µg/ml. |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa. |
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IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). -
組織特異性
Isoform 3 is expressed in liver. -
関連疾患
Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC) [MIM:277380]; also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12. -
配列類似性
Belongs to the LIMR family. LMBRD1 subfamily. -
翻訳後修飾
N-glycosylated. -
細胞内局在
Lysosome membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 55788 Human
- Omim: 612625 Human
- SwissProt: Q9NUN5 Human
- Unigene: 271643 Human
- Unigene: 677072 Human
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別名
- HDAg-L-interacting protein NESI antibody
- LMBD1_HUMAN antibody
- LMBR1 domain-containing protein 1 antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence - Anti-LMBRD1 antibody (ab105419)Immunofluorescence of LMBRD1 in Human brain tissue with ab105419 at 20 ug/mL.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMBRD1 antibody (ab105419)Immunohistochemistry of LMBRD1 in Human brain tissue with ab105419 at 2.5 μg/mL.
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Western blot - Anti-LMBRD1 antibody (ab105419)Anti-LMBRD1 antibody (ab105419) at 1 µg/ml + Human brain tissue lysate at 15 µg
Predicted band size: 61 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab105419 は論文での使用が確認できていません。