Anti-LKB1 (phospho T189) 抗体 (ab60987)
Key features and details
- Rabbit polyclonal to LKB1 (phospho T189)
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-LKB1 (phospho T189) antibody
LKB1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to LKB1 (phospho T189) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide corresponding to Human LKB1 (phospho T189).
Database link: Q15831 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab60987の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa).
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| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa). |
ターゲット情報
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機能
Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor. -
組織特異性
Ubiquitously expressed. Strongest expression in testis and fetal liver. -
関連疾患
Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms. -
配列類似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
Contains 1 protein kinase domain. -
翻訳後修飾
Phosphorylated by a cAMP-dependent protein kinase. -
細胞内局在
Nucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2. - Information by UniProt
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参照データベース
- Entrez Gene: 20869 Mouse
- SwissProt: Q9WTK7 Mouse
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別名
- hLKB1 antibody
- Liver kinase B1 antibody
- LKB1 antibody
see all
画像
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Western blot - Anti-LKB1 (phospho T189) antibody (ab60987)All lanes : Anti-LKB1 (phospho T189) antibody (ab60987) at 1/500 dilution
Lane 1 : Extracts from NIH/3T3 cells,
treated with PMA (125ng/ml, 30mins).
Lane 2 : Extracts from NIH/3T3 cells,
treated with PMA (125ng/ml, 30mins) with immunizing phosphopeptide
Predicted band size: 48 kDa
Observed band size: 60 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab60987 は論文での使用が確認できていません。