JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB262931

Anti-LIN52 抗体

Anti-LIN52 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal LIN52 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LIN52 aa 1 to C-terminus.

別名を表示する

C14orf46, LIN52, Protein lin-52 homolog

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-LIN52 antibody (AB262931)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LIN52 antibody (AB262931)

PFA-fixed, Triton X-100 permeabilized human RH-30 cells stained for LIN52 (green) using ab262931 at 4 µg/ml in ICC/IF.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human LIN52 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q52LA3

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chicken": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

LIN52 also known as LINC01143 is a protein with a molecular mass of approximately 14 kDa. Mechanically LIN52 plays a role in regulating the cell cycle and transcription processes. It interacts with other proteins to form complexes that are important for controlling cellular processes. LIN52 is widely expressed in various tissues including the brain placenta and ovary indicating its significant contribution to multiple cell functions throughout the body.
Biological function summary

LIN52 is part of the DREAM complex which is involved in cell cycle regulation. This complex is essential for the repression of E2F-target genes during the quiescent phase of the cell cycle thereby inhibiting premature cell progression. LIN52's interaction with other elements of the DREAM complex allows for proper cell cycle arrest and its dysfunction can lead to uncontrolled cell proliferation.

Pathways

LIN52 is involved in the regulation of the cell cycle and transcription pathways. In the context of the cell cycle pathway it works alongside proteins like RB (Retinoblastoma) E2F and other members of the DREAM complex to maintain proper cell cycle control and response to proliferative signals. LIN52 also participates in transcription regulation pathways interacting with other transcriptional factors to modulate gene expression in response to cellular needs.

LIN52 dysfunction or altered expression is associated with several cancer types including ovarian and breast cancers. Its role in the DREAM complex links it to proteins such as RB whose mutations or inactivation are common in these cancers. LIN52's involvement in cell cycle control makes it a target of interest for understanding and potentially treating disorders characterized by abnormal cell growth.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

See full target information LIN52
style
left-column
style
left-column
style
right-column

組合せ製品

Primary Antibodies

AB138425

Anti-LIN54 antibody

Immunoprecipitation - Anti-LIN54 antibody (AB138425)

  • 0
  • 0
Primary Antibodies

AB214230

Anti-LIN9/TGS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIN9/TGS antibody (AB214230)

  • 0
  • 0
Primary Antibodies

AB254336

Anti-MTF2 antibody [EPR23536-87] - ChIP Grade

RabMAb|Recombinant

ChIP - Anti-MTF2 antibody [EPR23536-87] - ChIP Grade (AB254336)

  • 5
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com