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AB20943

Anti-Legionella pneumophila 抗体

Anti-Legionella pneumophila antibody

5

(1 Review)

|

(5 Publications)

Rabbit Polyclonal Legionella pneumophila antibody. Suitable for ELISA, Conjugation, ICC/IF and reacts with Legionella pneumophila samples. Cited in 5 publications. Immunogen corresponding to Cell preparation containing Legionella pneumophila protein.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Legionella pneumophila

アプリケーション

ELISA, ICC/IF, Conjugation

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

Reacts with L. pneumophila serogroups 1-12 in IFA. Recognizes all antigens of intact microorganism. Antiserum is not absorbed and may cross-react with related microorganisms

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "Conjugation" : {"fullname" : "Conjugation", "shortname":"Conjugation"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Legionella pneumophila": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "Conjugation-species-checked": "guaranteed", "Conjugation-species-dilution-info": "", "Conjugation-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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下記製品にもご興味をお持ちいただけるかもしれません:

AB247197

Legionella Pneumophila IgG ELISA kit

0

0 Reviews

製品ページを見る
こちらの製品も推奨する理由

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.1% Sodium azide Constituents: 0.0268% PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Legionella pneumophila often recognized by its popular alternate name Legionella p. is a bacterium with a mass of approximately 2 megadaltons. This pathogen has intricate machinery that manipulates host cell functions to favor its own replication. It expresses virulence factors within host cells often targeting macrophages. These virulence factors include the Dot/Icm Type IV secretion system which plays an important role in its pathogenicity. Legionella pneumophila's ability to evade destruction by host immune systems highlights its sophisticated mechanisms.
Biological function summary

Legionella pneumophila manipulates cellular processes to create a favorable niche for its replication. It forms a specialized compartment known as the Legionella-containing vacuole (LCV) within host cells. The bacterium achieves this by modulating host vesicle trafficking pathways avoiding lysosomal degradation. The LCV selectively recruits endoplasmic reticulum-derived vesicles helping Legionella establish a niche distinct from those normally used by other intracellular pathogens. This process promotes bacterial survival and replication within the host cell cytoplasm.

Pathways

Legionella pneumophila is integrally involved with host autophagy and apoptosis pathways. It possesses proteins that intervene in these cellular pathways to suppress apoptosis of infected cells prolonging its survival. It also hijacks the host's secretory pathway to modulate the transport and secretion of cellular components effectively manipulating host cell functions. The manipulation of pathways involves interactions with host proteins such as Rab1 which is important for its replication and survival.

Legionella pneumophila is primarily associated with Legionnaires' disease and Pontiac fever. These illnesses are results of respiratory infections caused by inhaling aerosolized water droplets containing the bacterium. In Legionnaires' disease the pathogen's interaction with macrophage proteins such as TNF-α and IL-6 highlights its ability to trigger a robust immune response which contributes to the clinical manifestations of the disease. The bacterium's virulence factors are critical in influencing the severity and progression of these infections.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Legionella pneumophila
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Biosensors 12: PubMed35735528

2022

Investigation of Conditions for Capture of Live with Polyclonal and Recombinant Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Lucas Paladines,Walid M Hassen,Juliana Chawich,Stefan Dübel,Simon Lévesque,Jan J Dubowski,Eric H Frost

Molecular cell 81:4527-4539.e8 PubMed34407442

2021

Structural and mechanistic basis for protein glutamylation by the kinase fold.

Applications

Unspecified application

Species

Unspecified reactive species

Adam Osinski,Miles H Black,Krzysztof Pawłowski,Zhe Chen,Yang Li,Vincent S Tagliabracci

Cell death and differentiation 28:2957-2969 PubMed34285384

2021

Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection.

Applications

Unspecified application

Species

Unspecified reactive species

Yaobin Liu,Rukmini Mukherjee,Florian Bonn,Thomas Colby,Ivan Matic,Marius Glogger,Mike Heilemann,Ivan Dikic

Molecular cell 77:164-179.e6 PubMed31732457

2019

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB.

Applications

Unspecified application

Species

Unspecified reactive species

Donghyuk Shin,Rukmini Mukherjee,Yaobin Liu,Alexis Gonzalez,Florian Bonn,Yan Liu,Vladimir V Rogov,Marcel Heinz,Alexandra Stolz,Gerhard Hummer,Volker Dötsch,Zhao-Qing Luo,Sagar Bhogaraju,Ivan Dikic

Proceedings of the National Academy of Sciences of 110:8212-7 PubMed23633572

2013

Surface display of a massively variable lipoprotein by a Legionella diversity-generating retroelement.

Applications

WB

Species

Unspecified reactive species

Diego Arambula,Wenge Wong,Bob A Medhekar,Huatao Guo,Mari Gingery,Elizabeth Czornyj,Minghsun Liu,Sanghamitra Dey,Partho Ghosh,Jeff F Miller
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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