Anti-LDL (Copper oxidized) 抗体 (ab14519)
Key features and details
- Rabbit polyclonal to LDL (Copper oxidized)
- Suitable for: ELISA, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-LDL (Copper oxidized) antibody -
製品の詳細
Rabbit polyclonal to LDL (Copper oxidized) -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Human Cu2+ oxidised LDL.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab14519の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA | ||
IHC-P | (2) |
特記事項 |
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IHC-P: <1/500.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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関連性
When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. Oxidized lipoproteins are formed by free radical damage to lipids that accumulate in macrophages and smooth muscle cells causing foam cell formation, an initial step in the disease. -
細胞内局在
Secreted (probable)
データシートおよび資料
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Datasheet download
参考文献 (11)
ab14519 は 11 報の論文で使用されています。
- Zha S et al. Topical Simvastatin Improves Lesions of Diffuse Normolipemic Plane Xanthoma by Inhibiting Foam Cell Pyroptosis. Front Immunol 13:865704 (2022). PubMed: 35619689
- Wang P et al. LDL-induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction. Mol Med Rep 24:N/A (2021). PubMed: 34036387
- Jing J et al. Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells. Cell Death Dis 11:626 (2020). PubMed: 32796811
- Redinus K et al. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight 4:N/A (2019). PubMed: 31391342
- Zhang R et al. FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice. Biomed Res Int 2019:3514574 (2019). PubMed: 31534958