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AB308422

Anti-Lassa virus Nucleoprotein 抗体 [HL1390]

Anti-Lassa virus Nucleoprotein antibody [HL1390]

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Rabbit Recombinant Monoclonal Lassa virus Nucleoprotein antibody. Carrier free. Suitable for WB and reacts with Transfected cell line - Mammarenavirus lassaense samples.

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

HL1390

アイソタイプ

IgG

キャリアフリー

Yes

交差種

Mammarenavirus lassaense

アプリケーション

WB

applications

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組合せ製品

Proteins & Peptides

AB273530

Recombinant Human coronavirus SARS-CoV-2 nucleocapsid protein (His tag)

ELISA - Recombinant Human coronavirus SARS-CoV-2 nucleocapsid protein (His tag) (AB273530)

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Primary Antibodies

AB271180

Rabbit monoclonal [EPR24334-118] to SARS-CoV-2 nucleocapsid protein

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Rabbit monoclonal [EPR24334-118] to SARS-CoV-2 nucleocapsid protein (AB271180)

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Sample Prep & Detection Kits

AB102918

PE / R-Phycoerythrin Conjugation Kit - Lightning-Link®

Flow Cytometry - PE / R-Phycoerythrin Conjugation Kit - Lightning-Link® (AB102918)

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  • 2
Proteins & Peptides

AB7460

Recombinant Protein G (HRP)

Western blot - Recombinant Protein G (HRP) (AB7460)

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  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mammarenavirus lassaense": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Transfected cell line - Mammarenavirus lassaense": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>" } } }
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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
+4°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

LASV NP also known as Lassa virus nucleoprotein or NP is a structural protein with a mass of approximately 63 kDa. It plays an important role in the replication cycle of Lassa virus a member of the Arenaviridae family. Expressed primarily in infected host cells NP assists in the formation of viral ribonucleoprotein complexes. This protein encapsidates the viral RNA genome safeguarding it from degradation and interacting with the viral polymerase which is necessary for efficient viral replication and transcription.
Biological function summary

This nucleoprotein serves a multifunctional role in viral propagation and immune evasion. In addition to its RNA-binding properties NP suppresses the host's innate immune responses by interfering with interferon signaling pathways. It accomplishes this by degrading double-stranded RNA thereby preventing activation of the pathway. NP is not known to be part of a larger complex but operates closely with other viral components to enhance viral survival and replication within host cells.

Pathways

LASV NP is implicated importantly in the viral life cycle and immune evasion mechanisms. The interferon signaling pathway is significantly impacted by NP's ability to counteract interferon responses which normally aid in defense against viral infections. NP cooperates with the Lassa virus glycoprotein complex and matrix protein in these pathways coordinating processes that facilitate successful viral replication and assembly while concurrently subverting host immune defenses.

LASV NP is closely associated with Lassa fever a severe viral hemorrhagic illness endemic in parts of West Africa. The NP's role in immune system modulation connects it with an increased virulence of the virus therefore contributing to the pathogenesis of Lassa fever. Additionally interactions between NP and the host immune-modulating proteins such as those in the interferon family influence the disease progression and host immune response making it a target of interest for antiviral therapies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Lassa virus Nucleoprotein
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Abcam product promise

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