AB187370

Anti-Lambda Light chain 抗体 [LcN-2]

Name: Anti-Lambda Light chain 抗体 [LcN-2] (ab187370) | Abcam
Brand: Abcam Limited
SKU: AB187370
Price: 74000 JPY
Availability: InStock

Anti-Lambda Light chain antibody [LcN-2]

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(3 Publications)

Mouse Monoclonal LV151 antibody. Suitable for ICC, WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human IGLV1-51.

別名を表示する

Immunoglobulin lambda variable 1-51, Ig lambda chain V-I region BL2, Ig lambda chain V-I region EPS, Ig lambda chain V-I region NEW, Ig lambda chain V-I region NIG-64, IGLV1-51

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human tonsil tissue labeling Lambda Light chain with ab187370 at 1 μg/ml.

Supplier Data

Immunocytochemistry - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

Immunocytochemistry analysis of Ramos (human Burkitt's lymphoma cell line) cells using ab187370 (AF488-labeled) (Green). DAPI was used to stain the cell nuclei (blue). Imaged using confocal microscopy.

Supplier Data

Western blot - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

All lanes:

Western blot - Anti-Lambda Light chain antibody [LcN-2] (ab187370) at 1 µg/mL

All lanes:

Human intestine lysate

Predicted band size: 23 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

LcN-2

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

キャリアフリー

交差種

Human

アプリケーション

IHC-P, WB, ICC

applications

免疫原

Native Full Length Protein corresponding to Human IGLV1-51.

P01701

特異性

ab187370 is specific to lambda light chain of immunoglobulin and shows no cross-reaction with kappa light chain or any of the five heavy chains.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1-2 µg/mL", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.25-0.5 µg/mL", "IHCP-species-notes": "Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 minutes." } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

精製に関する特記事項

ab187370 was purified from Bioreactor Concentrate by Protein A/G.

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Lambda Light Chain also known as lambda chain or lambda protein forms a part of immunoglobulins (antibodies). Its mass typically ranges between 22 to 24 kDa. This protein is expressed primarily in B cells. Specifically it pairs with heavy chains to form the complete antibody molecule. It participates in the antigen recognition process supporting the immune system's defense mechanisms.

Biological function summary

Lambda Light Chain participates in immunological functions by contributing to the antigen-binding site of antibodies. It exists as a part of the immunoglobulin complex. The lambda chain alongside heavy chains forms the variable part of antibodies allowing specificity in antigen recognition. Its variation leads to a diverse antibody repertoire which is important for recognizing a wide range of pathogens.

Pathways

Lambda Light Chain fits into pathways involving adaptive immune responses. It is important in antigen processing and presentation pathways. In this context it interacts with the heavy chains which together drive the specificity and efficiency of immune response pathways. It also associates with proteins like the major histocompatibility complex (MHC) which facilitates antigen presentation to T cells.

Lambda Light Chain associates with multiple myeloma a cancer of plasma cells and light chain amyloidosis a disorder where light chains accumulate as amyloid fibrils in tissues. In these conditions proteins like immunoglobulin heavy chain and albumin often interact with or are affected by lambda chains providing insights into disease mechanisms and potential targets for therapeutic intervention.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed : 24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268).

See full target information IGLV1-51

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Materials today. Bio 35:102288 PubMed40978162

2025

Bioinspired nanoparticles prevent blue-light-induced skin hyperpigmentation via FZD2-TYR-melanin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqi Chen,Tong Wu,Zijun Chen,Jia Zhang,Yuqi Zhou,Qi Wang,Bo Wang,Zeqian Wang,Xiaodong Jin,Shishi Xiong,Tong Zhang,Shanshan Gao,Jingjing Ma,Ziwei Deng,Xutao Chen,Chunying Li,Zhe Jian

Oncotarget 12:366-378 PubMed33659047

2021

Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2.

Applications

Unspecified application

Species

Unspecified reactive species

Yin-Ling Zhang,Geng Xue,Hui Miao,Chuan-Chuan Zhou,Shu-Han Sun,Yi Zhang

Clinical and molecular hepatology : PubMed33465844

2021

Serum Lipocalin-2 is a Potential Biomarker for the Clinical Diagnosis of Nonalcoholic Steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Xu,Yu-Min Wang,Miao-Miao Ying,Sui-Dan Chen,Zong-Rui Li,Hong-Lei Ma,Ming-Hua Zheng,Jian Wu,Chun-Ming Ding

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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Anti-Lambda Light chain 抗体 [LcN-2]

Anti-Lambda Light chain antibody [LcN-2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

Immunocytochemistry - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

Western blot - Anti-Lambda Light chain antibody [LcN-2] (AB187370)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

代替製品

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組合せ製品

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Secondary Antibodies

Abcam product promise