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AB252538

Anti-Kv4.3/KCND3 抗体 [K75/41]

Anti-Kv4.3/KCND3 antibody [K75/41]

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Mouse Recombinant Monoclonal Kv4.3/KCND3 antibody. Suitable for IHC-P and reacts with Mouse, Rat samples.

別名を表示する

A-type voltage-gated potassium channel KCND3, Potassium voltage-gated channel subfamily D member 3, Voltage-gated potassium channel subunit Kv4.3, Kcnd3

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)

Immunohistochemical analysis of paraffin-embedded mouse cerebrum tissue labeling Kv4.3/KCND3 with ab252538 at 1/200 dilution, followed by secondary LeicaDS9800 (Bond™ Polymer Refine Detection). Positive staining on the mouse cerebrum. The section was incubated with ab252538 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counter stained with Hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, followed by LeicaDS9800 (Bond™ Polymer Refine Detection).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)

Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue labeling Kv4.3/KCND3 with ab252538 at 1/200 dilution, followed by secondary LeicaDS9800 (Bond™ Polymer Refine Detection). Negative control : no staining on the mouse skeletal muscle. The section was incubated with ab252538 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counter stained with Hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, followed by LeicaDS9800 (Bond™ Polymer Refine Detection).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)

Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue labeling Kv4.3/KCND3 with ab252538 at 1/200 dilution, followed by secondary LeicaDS9800 (Bond™ Polymer Refine Detection). Negative control : no staining on the rat skeletal muscle. The section was incubated with ab252538 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counter stained with Hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, followed by LeicaDS9800 (Bond™ Polymer Refine Detection).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 20 mins.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.3/KCND3 antibody [K75/41] (AB252538)

Immunohistochemical analysis of paraffin-embedded rat cerebrum tissue labeling Kv4.3/KCND3 with ab252538 at 1/200 dilution, followed by secondary LeicaDS9800 (Bond™ Polymer Refine Detection). Positive staining on the rat cerebrum. The section was incubated with ab252538 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counter stained with Hematoxylin.

Secondary antibody only control : Used PBS instead of primary antibody, followed by LeicaDS9800 (Bond™ Polymer Refine Detection).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 20 mins.

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-Kv4.3/KCND3 antibody [K75/41] - BSA and Azide free

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

K75/41

アイソタイプ

IgG1

キャリアフリー

No

交差種

Mouse, Rat

アプリケーション

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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組合せ製品

Primary Antibodies

AB307710

Anti-Kv4.2/KCND2 antibody [EPR26384-89]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv4.2/KCND2 antibody [EPR26384-89] (AB307710)

  • 0
  • 0
Primary Antibodies

AB283689

Anti-Insulin Receptor alpha antibody [EPR23962-157]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Insulin Receptor alpha antibody [EPR23962-157] (AB283689)

  • 0
  • 0
Primary Antibodies

AB27853

Anti-PLVAP/PV-1 antibody [MECA-32]

BOND RX™ Validated|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PLVAP/PV-1 antibody [MECA-32] (AB27853)

  • 5
  • 1
Primary Antibodies

AB236872

Anti-PBK/SPK antibody [EPR21983]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBK/SPK antibody [EPR21983] (AB236872)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Kv4.3 also known as KCND3 is a voltage-gated potassium channel subunit with an important role in membrane repolarization. This protein with a mass of approximately 71 kDa is extensively expressed in the heart and brain. Kv4.3 contributes to the formation of transient outward potassium currents (Ito) that are essential for shaping the action potentials in neurons and cardiac myocytes. These currents help in the rapid repolarization phase that restores the resting membrane potential after depolarization.
Biological function summary

Kv4.3 influences electrical signaling and cellular excitability in the cardiovascular and nervous systems. It often forms complexes with auxiliary subunits such as KChIP1-4 (Kv channel-interacting proteins) which modulate its current properties and localization. In neurons Kv4.3 helps regulate firing patterns while in cardiac tissue it affects heart rate and contractility. The presence of these complexes ensures precise control of channel function fitting the specific needs of tissue type and physiological condition.

Pathways

Kv4.3 integrates into critical signaling networks that involve ion homeostasis and action potential propagation. It belongs to the pathway that manages membrane potential dynamics interacting with proteins like Kv4.2 and Kv2.1 as part of a broader set of voltage-gated potassium channels. This network plays a role in the Wnt signaling pathway impacting cellular processes such as cell cycle regulation and differentiation.

Kv4.3 has been linked with cardiac arrhythmias and neurological disorders. Altered Kv4.3 functionality can lead to improper cardiac electrical activity resulting in arrhythmic events such as Long QT Syndrome. In the brain aberrations in Kv4.3 channel activity can correlate with epilepsy where disrupted ion channel regulation triggers excessive neuronal firing. Its involvement in these conditions highlights its participation in concert with other related proteins like SCN5A in cardiac tissues and CACNA1H in neuronal contexts.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (By similarity). In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (By similarity).
See full target information Kcnd3
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Abcam product promise

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