Anti-Keratin 77 抗体

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Keratin 77 functions as a critical component in skin barrier function and keratinocyte differentiation. It integrates into complex networks of intermediate filaments that provide tensile strength to cells. This keratin participates in maintaining the rigidity and elasticity of the skin by combining with other keratins like KRT5 and KRT14 constituting a keratin filament complex necessary for proper skin function. The presence of keratin 77 in hair follicles also suggests a role in hair structure and growth.

Pathways

Keratin 77 is deeply involved in several skin differentiation and repair pathways. It interacts with proteins such as filaggrin and loricrin in the epidermal differentiation complex supporting the skin barrier's protective function. In the wound healing pathway keratin 77 modulates cellular response and organization within the epidermis working alongside proteins like involucrin to facilitate skin repair processes.