Anti-KDEL Receptor 抗体 [KR-10] (ab69659)
![Western blot - Anti-KDEL Receptor antibody [KR-10] (ab69659)](https://www.abcam.co.jp/ps/products/69/ab69659/Images/ab69659-450900-AntiKDEL-Receptor-antibody-western-blot.png "Western blot - Anti-KDEL Receptor antibody [KR-10] (ab69659)")
Key features and details
- Mouse monoclonal [KR-10] to KDEL Receptor
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG1
製品の概要
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製品名
Anti-KDEL Receptor antibody [KR-10]
KDEL Receptor 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [KR-10] to KDEL Receptor -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide corresponding to Cow KDEL Receptor aa 192-212 conjugated to keyhole limpet haemocyanin. 21 residue synthetic peptide.
Sequence:CDFFYLYITKVLKGKKLSLPA
Database link: Q99JH8 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
KR-10 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab69659の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
1/1000. Predicted molecular weight: 24 kDa.
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| 特記事項 |
|---|
|
WB
1/1000. Predicted molecular weight: 24 kDa. |
ターゲット情報
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機能
Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. -
配列類似性
Belongs to the ERD2 family. -
翻訳後修飾
Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function. -
細胞内局在
Cytoplasmic vesicle, COPI-coated vesicle membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 361577 Rat
- SwissProt: Q569A6 Rat
- Unigene: 1819 Rat
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別名
- ER lumen protein retaining receptor 1 antibody
- ER lumen protein-retaining receptor 1 antibody
- ERD 2 antibody
see all
画像
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Western blot - Anti-KDEL Receptor antibody [KR-10] (ab69659)Anti-KDEL Receptor antibody [KR-10] (ab69659) at 1/1000 dilution + Rat tissue lysate at 15 µg
Secondary
Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
Predicted band size: 24 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (11)
ab69659 は 11 報の論文で使用されています。
- Chiu M et al. Diverse cellular morphologies during lumen maturation in Anopheles gambiae larval salivary glands. Insect Mol Biol 30:210-230 (2021). PubMed: 33305876
- Dai Z et al. Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. PLoS Genet 16:e1009140 (2020). PubMed: 33057338
- Bikard Y et al. The KDEL receptor has a role in the biogenesis and trafficking of the epithelial sodium channel (ENaC). J Biol Chem 294:18324-18336 (2019). PubMed: 31653700
- Bartels AK et al. KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases. Cell Physiol Biochem 52:850-868 (2019). PubMed: 30958660
- Lo Piccolo L et al. FUS toxicity is rescued by the modulation of lncRNA hsr? expression in Drosophila melanogaster. Sci Rep 7:15660 (2017). PubMed: 29142303