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Anti-KCNA5/KV1-5 抗体 [2D10.D6] (ab184691)

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Western blot - Anti-KCNA5/KV1-5 antibody [2D10.D6] (ab184691)

    Key features and details

    • Mouse monoclonal [2D10.D6] to KCNA5/KV1-5
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG1

    製品の概要

    • 製品名

      Anti-KCNA5/KV1-5 antibody [2D10.D6]
      KCNA5/KV1-5 一次抗体 製品一覧

    • 製品の詳細

      Mouse monoclonal [2D10.D6] to KCNA5/KV1-5

    • 由来種

      Mouse

    • アプリケーション

      適用あり: WBmore details

    • 種交差性

      交差種: Human

    • 免疫原

      Synthetic peptide corresponding to Human KCNA5/KV1-5 aa 50-150 conjugated to keyhole limpet haemocyanin.
      Database link: P22460

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • ポジティブ･コントロール

      • Human brain (hippocampus) tissue lysate; Rat brain tissue.

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab184691の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    WB
    1/100 - 1/1000. Predicted molecular weight: 67 kDa.
    特記事項
    WB
    1/100 - 1/1000. Predicted molecular weight: 67 kDa.

    ターゲット情報

    • 機能

      Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.

    • 組織特異性

      Pancreatic islets and insulinoma.

    • 関連疾患

      Defects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.

    • 配列類似性

      Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.

    • ドメイン

      The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
      The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    • 翻訳後修飾

      Sumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    • 参照データベース

      • 別名

        • ATFB7 antibody
        • cardiac potassium channel antibody
        • HCK1 antibody
        • HK2 antibody
        • HPCN1 antibody
        • insulinoma and islet potassium channel antibody
        • KCNA5 antibody
        • KCNA5_HUMAN antibody
        • KV1.5 antibody
        • PCN1 antibody
        • potassium channel 1 antibody
        • Potassium channel, insulinoma and islet cell antibody
        • Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody
        • Potassium voltage gated channel subfamily A member 5 antibody
        • Potassium voltage-gated channel subfamily A member 5 antibody
        • Voltage-gated potassium channel HK2 antibody
        • voltage-gated potassium channel protein Kv1.5 antibody
        • Voltage-gated potassium channel subunit Kv1.5 antibody
        see all

      画像

      • Western blot - Anti-KCNA5/KV1-5 antibody [2D10.D6] (ab184691)
        Western blot - Anti-KCNA5/KV1-5 antibody [2D10.D6] (ab184691)
        All lanes : Anti-KCNA5/KV1-5 antibody [2D10.D6] (ab184691) at 1/200 dilution

        All lanes : Human brain hippocampus tissue lysate

        Lysates/proteins at 5 µg per lane.

        Predicted band size: 67 kDa

      参考文献 (0)

      ab184691 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab184691 は論文での使用が確認できていません。

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