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Anti-KAT7 / Hbo1 / MYST2 抗体 (ab37289)

Submit a review Q&A (1)References (3)
Western blot - Anti-KAT7 / Hbo1 / MYST2 antibody (ab37289)

    Key features and details

    • Rabbit polyclonal to KAT7 / Hbo1 / MYST2
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    リコンビナント抗体で、ロット間での高い再現性を実現

    Product image
    Anti-KAT7 / Hbo1 / MYST2 antibody [EPR18473] - BSA and Azide free (ab240315)
    • 異なるロット間での安定した再現性
    • 容易なスケールアップ
    • 評価試験による特異性の確認済み
    • 倫理基準に準拠 - アニマル・フリーの生産

    製品の概要

    • 製品名

      Anti-KAT7 / Hbo1 / MYST2 antibody
      KAT7 / Hbo1 / MYST2 一次抗体 製品一覧

    • 製品の詳細

      Rabbit polyclonal to KAT7 / Hbo1 / MYST2

    • 由来種

      Rabbit

    • アプリケーション

      適用あり: WBmore details

    • 種交差性

      交差種: Human

    • 免疫原

      Synthetic peptide corresponding to Human KAT7/ Hbo1/ MYST2 (N terminal).
      Database link: O95251

    • 特記事項

      This product is manufactured by BioVision, an Abcam company and was previously called 3692 HAT-2 Antibody. 3692-100 is the same size as the 100 µg size of ab37289.

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab37289の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    WB
    Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).
    特記事項
    WB
    Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).

    ターゲット情報

    • 機能

      Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.

    • 組織特異性

      Ubiquitously expressed, with highest levels in testis.

    • 配列類似性

      Belongs to the MYST (SAS/MOZ) family.
      Contains 1 C2HC-type zinc finger.

    • ドメイン

      The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
      The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.

    • 翻訳後修飾

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • 細胞内局在

      Nucleus > nucleoplasm.
    • Information by UniProt

    • 参照データベース

      • 別名

        • Hbo 1 antibody
        • HBO1 antibody
        • HBOa antibody
        • Histone acetyltransferase binding to hORC1 antibody
        • Histone acetyltransferase binding to ORC1 antibody
        • Histone acetyltransferase KAT7 antibody
        • Histone acetyltransferase MYST2 antibody
        • K(lysine) acetyltransferase 7 antibody
        • KAT 7 antibody
        • KAT7 antibody
        • Lysine acetyltransferase 7 antibody
        • MOZ antibody
        • MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody
        • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody
        • MYST 2 antibody
        • MYST histone acetyltransferase 2 antibody
        • MYST protein 2 antibody
        • MYST-2 antibody
        • MYST2 antibody
        • MYST2_HUMAN antibody
        • SAS 2 antibody
        • SAS2 and TIP60 protein 2 antibody
        • TIP60 protein 2 antibody
        • YBF2/SAS3 antibody
        • ZC2HC7 antibody
        see all

      画像

      • Western blot - Anti-KAT7 / Hbo1 / MYST2 antibody (ab37289)
        Western blot - Anti-KAT7 / Hbo1 / MYST2 antibody (ab37289)

      参考文献 (3)

      ab37289 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab37289 は 3 報の論文で使用されています。

      • Ma Y  et al. KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer. J Radiat Res 64:448-456 (2023). PubMed: 36724120
      • Schrötter A  et al. FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease. J Cell Sci 126:2480-92 (2013). PubMed: 23572515
      • Kueh AJ  et al. HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development. Mol Cell Biol 31:845-860 (2011). IHC-P ; Mouse . PubMed: 21149574

      レビューと Q&A

      Show All レビュー Q&A
      レビューを送る 質問を送る

      Question

      might test ab31506 in xenopus, send testing discount code

      xenopus: NP001079995, check homology
      check homology of other Abs as well

      Read More
      Answer

      Thank you for your phone call.
      The overall homology between Human and Xenopus is 93%. Thus, in general there is good chance for an antibody raised against human to work in Xenopus.
      For ab31506 the homology of the immunogen with Xenopus is 100%.
      For ab87100 the homology of the immunogen with Xenopus is 90%. For the other Hbo1 antibodies I currently do not have information about the immunogen range. I can check with the lab if you like - please let me know.
      None of these antibodies has been tested in IP.
      DISCOUNT CODE: xxx
      Expiration date: xxx
      I am very pleased to hear you would like to accept our offer and test ab31506 in Xenopus and IP. This code will give you: 1 free PRIMARY ANTIBODY before the expiration date. To redeem this offer, please submit an Abreview for Xenopus/IP and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.
      Remember, we publish both positive and negative Abreviews on our datasheets so please submit the results of your tests. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.
      Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.
      The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount.

      Read More

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com