Anti-JP-2 抗体 (ab110056)
Key features and details
- Rabbit polyclonal to JP-2
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-JP-2 antibody
JP-2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to JP-2 -
由来種
Rabbit -
特異性
Multiple isoforms of JPH2 are known to exist. -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rat
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免疫原
Synthetic peptide corresponding to Human JP-2 (C terminal).
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ポジティブ･コントロール
- Human Heart and Skeletal Muscle. Mouse brain tissue lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab110056の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 75 kDa.
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| IHC-P |
Use a concentration of 5 µg/ml.
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| 特記事項 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 75 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. |
ターゲット情報
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機能
Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development. -
組織特異性
Specifically expressed in skeletal muscle and heart. -
関連疾患
Defects in JPH2 are the cause of cardiomyopathy familial hypertrophic type 17 (CMH17) [MIM:613873]. CMH17 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. -
配列類似性
Belongs to the junctophilin family.
Contains 8 MORN repeats. -
ドメイン
The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids. -
細胞内局在
Cell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. - Information by UniProt
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参照データベース
- Entrez Gene: 57158 Human
- Entrez Gene: 59091 Mouse
- Entrez Gene: 296345 Rat
- Omim: 605267 Human
- SwissProt: Q9BR39 Human
- SwissProt: Q9ET78 Mouse
- SwissProt: Q2PS20 Rat
- Unigene: 441737 Human
see all -
別名
- FLJ40969 antibody
- JP-2 antibody
- JP2 antibody
see all
画像
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Western blot - Anti-JP-2 antibody (ab110056)Lane 1 : Anti-JP-2 antibody (ab110056) at 1 µg/ml
Lane 2 : Anti-JP-2 antibody (ab110056) at 2 µg/ml
All lanes : Mouse brain tissue lysate
Predicted band size: 75 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JP-2 antibody (ab110056)ab110056 at 5 µg/ml staining JP-2 in Formalin-Fixed, Paraffin-Embedded Human Heart by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JP-2 antibody (ab110056)ab110056 at 5 µg/ml staining JP-2 in Formalin-Fixed, Paraffin-Embedded Human Skeletal Muscle by Immunohistochemistry.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab110056 は 1 報の論文で使用されています。
- Huang X et al. Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis. Front Endocrinol (Lausanne) 13:801260 (2022). PubMed: 35242109