Anti-Japanese encephalitis virus E glycoprotein 抗体 [JE1] (ab41671)
Key features and details
- Mouse monoclonal [JE1] to Japanese encephalitis virus E glycoprotein
- Suitable for: WB, ELISA, Dot blot, ICC/IF
- Reacts with: Japanese encephalitis virus
- Isotype: IgG2a
製品の概要
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製品名
Anti-Japanese encephalitis virus E glycoprotein antibody [JE1] -
製品の詳細
Mouse monoclonal [JE1] to Japanese encephalitis virus E glycoprotein -
由来種
Mouse -
アプリケーション
適用あり: WB, ELISA, Dot blot, ICC/IFmore details -
種交差性
交差種: Japanese encephalitis virus -
免疫原
Tissue, cells or virus corresponding to Japanese encephalitis virus Japanese encephalitis virus E glycoprotein.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.1% Proclin 150
Constituents: 10% BSA, 89.9% RPMI 1640 -
Concentration information loading...
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精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
JE1 -
アイソタイプ
IgG2a -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab41671の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use at an assay dependent concentration. PubMed: 21124882
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ELISA |
Use at an assay dependent concentration.
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Dot blot |
Use at an assay dependent concentration.
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ICC/IF |
1/5 - 1/20.
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特記事項 |
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WB
Use at an assay dependent concentration. PubMed: 21124882 |
ELISA
Use at an assay dependent concentration. |
Dot blot
Use at an assay dependent concentration. |
ICC/IF
1/5 - 1/20. |
ターゲット情報
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関連性
Japanese encephalitis virus E glycoprotein is one of three structural proteins encoded by the viral genome. It is thought to be involved in viral adhesion and entry into host cells, hemagglutination, cellular tropism, viral virulence, and the induction of protective immune responses. Japanese encephalitis (JE) is a Flaviviruses; these are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope glycoproteins M and E. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. Domains I and II are intertwined. Domain II can be divided into two structural components, both of which comprise alpha-beta sandwich folds. -
細胞内局在
membrane -
参照データベース
- SwissProt: O09754 Japanese encephalitis virus
- SwissProt: P27395 Japanese encephalitis virus
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別名
- Japanese encephalitis E glycoprotein antibody
- Japanese encephalitis envelope glycoprotein antibody
- Japanese encephalitis virus envelope glycoprotein antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab41671 は 9 報の論文で使用されています。
- Yang S et al. Japanese encephalitis virus perturbs PML-nuclear bodies by engaging in interactions with distinct porcine PML isoforms. Front Cell Infect Microbiol 13:1239234 (2023). PubMed: 37928180
- Soni N et al. Bone marrow-derived extracellular vesicles modulate the abundance of infiltrating immune cells in the brain and exert an antiviral effect against the Japanese encephalitis virus. FASEB Bioadv 4:798-815 (2022). PubMed: 36479206
- Tripathi A et al. Development and characterization of an animal model of Japanese encephalitis virus infection in adolescent C57BL/6 mouse. Dis Model Mech 14:N/A (2021). PubMed: 34447981
- Li XF et al. Visualization of a neurotropic flavivirus infection in mouse reveals unique viscerotropism controlled by host type I interferon signaling. Theranostics 7:912-925 (2017). PubMed: 28382163
- Nain M et al. GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells. J Virol 91:N/A (2017). PubMed: 28053106
- Li M et al. Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E. Virology 510:67-75 (2017). PubMed: 28710958
- Sharma M et al. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes. Autophagy 10:1637-51 (2014). PubMed: 25046112
- Das S et al. Critical role of lipid rafts in virus entry and activation of phosphoinositide 3' kinase/Akt signaling during early stages of Japanese encephalitis virus infection in neural stem/progenitor cells. J Neurochem 115:537-49 (2010). ICC/IF ; Mouse . PubMed: 20722967
- Nazmi A et al. Antiviral and neuroprotective role of octaguanidinium dendrimer-conjugated morpholino oligomers in Japanese encephalitis. PLoS Negl Trop Dis 4:e892 (2010). WB ; Japanese encephalitis virus . PubMed: 21124882