Anti-ITPKC 抗体 (ab188007)
Key features and details
- Rabbit polyclonal to ITPKC
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ITPKC antibody -
製品の詳細
Rabbit polyclonal to ITPKC -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-P, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment corresponding to Human ITPKC aa 250-400.
Database link: Q96DU7 -
ポジティブ･コントロール
- IHC-P:Human testis tissue WB: RT4 and U-251 MG sp cell lysates. ICC/IF: U-2OS cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab188007の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 75 kDa.
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| IHC-P |
1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
|
| 特記事項 |
|---|
|
WB
Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 75 kDa. |
|
IHC-P
1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
|
ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
ターゲット情報
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機能
Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. -
組織特異性
Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. -
関連疾患
Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries. -
配列類似性
Belongs to the inositol phosphokinase (IPK) family. -
細胞内局在
Nucleus. Cytoplasm. Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. - Information by UniProt
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参照データベース
- Entrez Gene: 80271 Human
- Omim: 606476 Human
- SwissProt: Q96DU7 Human
- Unigene: 515415 Human
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別名
- 4 antibody
- 5-trisphosphate 3-kinase C antibody
- Inositol 1 antibody
see all
画像
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Western blot - Anti-ITPKC antibody (ab188007)All lanes : Anti-ITPKC antibody (ab188007) at 1/500 dilution
Lane 1 : RT4 cell lysate
Lane 2 : U-251MG sp cell lysate
Predicted band size: 75 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-ITPKC antibody (ab188007)Immunocytochemistry/immunofluorescent analysis of U-2OS cells staining ITPKC antibody with ab18807 at 1μg/ml (green).
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPKC antibody (ab188007)Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling ITPKC with ab188007 at 1/1000 dilution.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab188007 は論文での使用が確認できていません。