AB197672

Anti-ITGB6 抗体

Name: Anti-ITGB6 抗体 (ab197672) | Abcam
Brand: Abcam Limited
SKU: AB197672
Price: 75000 JPY
Availability: InStock

Anti-ITGB6 antibody

Be the first to review this product! Submit a review

(4 Publications)

Rabbit Polyclonal ITGB6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to Integrin beta-6, fused to Integrin beta-6.

別名を表示する

Integrin beta-6, ITGB6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling ITGB6 with ab197672 at 1/10 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling ITGB6 with ab197672 at 1/10 dilution.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Fusion protein corresponding to Integrin beta-6, fused to Integrin beta-6. The exact immunogen used to generate this antibody is proprietary information.

P18564

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein ITGB6 also known as Integrin beta-6 is a part of the integrin family which are transmembrane receptors. ITGB6 has a molecular mass of approximately 88 kDa. It functions mechanically by binding to extracellular matrix proteins such as fibronectin vitronectin and tenascin. ITGB6 pairs exclusively with the integrin alpha-V subunit to form the integrin alpha-V beta-6 (αvβ6) heterodimer. Its expression mainly occurs in epithelial cells particularly in the skin lungs and gastrointestinal tract.

Biological function summary

ITGB6 plays important roles in cell adhesion migration and signaling. It is part of the αv integrin complex which is significant in the regulation of transforming growth factor-beta (TGF-β) activation. This activation influences epithelial-mesenchymal transition (EMT) tissue repair and fibrosis. ITGB6 impacts processes such as inflammation and wound healing due to its expression in epithelial tissues thereby contributing to maintaining tissue integrity and function.

Pathways

ITGB6 interacts in the TGF-β signaling and epithelial cell migration pathways. TGF-β activation via ITGB6 plays a critical role in controlling immune responses and cellular proliferation. ITGB6 is interconnected with other integrin family members such as ITGAV (Integrin alpha-V) which collaborates in cellular mechanisms involving cell adhesion and signaling processes. These interactions contribute to cellular responses to extracellular signals that influence pathophysiological processes.

ITGB6 has associations with fibrosis and cancer. In fibrotic diseases ITGB6 facilitates excess activation of TGF-β leading to aberrant tissue remodeling in organs such as the lungs and liver. Regarding cancer ITGB6 influences tumor progression and metastasis particularly in epithelial-derived cancers due to its role in EMT and tissue invasion. ITGB6's interactions with other integrins and ECM proteins contribute to tumorigenesis and fibrotic tissue changes making it a therapeutic target in these conditions.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Integrin alpha-V : beta-6 (ITGAV : ITGB6) is a receptor for fibronectin and cytotactin (PubMed : 17158881, PubMed : 17545607). It recognizes the sequence R-G-D in its ligands (PubMed : 17158881, PubMed : 17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed : 17158881, PubMed : 17545607). ITGAV : ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed : 17158881). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 15184403, PubMed : 22278742, PubMed : 28117447).. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed : 24367260).

See full target information Integrin beta-6

style

left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0328263 PubMed40680053

2025

Odontogenesis-associated phosphoprotein (ODAPH) Promotes Ameloblast adhesion and alkaline phosphatase (ALP) expression via LAMC2/ ITGB6/TGF-β1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mingyue Li,Jie Zhang,Shuang Xiao,Xinyang Liu,Shuai Song,Xiaoyuan Ye,Ruonan Bi,Yuguang Gao,Li Zhang

Journal of biochemical and molecular toxicology 38:e23693 PubMed38622980

2024

IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Ling,Guangbin Ye,Chunyan Qin,Xianjiu Liao,Ruirui Yang,Lili Su,Guangzi Qi

Frontiers in oncology 11:759586 PubMed34976806

2021

Systematic Analysis of an Invasion-Related 3-Gene Signature and Its Validation as a Prognostic Model for Pancreatic Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dafeng Xu,Yu Wang,Yuliang Zhang,Zhehao Liu,Yonghai Chen,Jinfang Zheng

Clinical epigenetics 13:141 PubMed34289901

2021

Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Yuan Feng,Bing-Bing Yan,Yong-Zhi Huang,Li Li

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ITGB6 抗体

Anti-ITGB6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise