AB75224

Anti-ITGA7 抗体

Name: Anti-ITGA7 抗体 (ab75224) | Abcam
Brand: Abcam Limited
SKU: AB75224
Price: 76000 JPY
Availability: InStock
Rating: 4 (3 reviews)

Anti-ITGA7 antibody

(3 Reviews)

(6 Publications)

Rabbit Polyclonal ITGA7 antibody. Suitable for ELISA, WB, IHC-Fr, IHC-P and reacts with Human, African green monkey samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA7.

別名を表示する

UNQ406/PRO768, ITGA7, Integrin alpha-7

1 Images

Unknown

Western blot - Anti-ITGA7 antibody (AB75224)

All lanes:

Western blot - Anti-ITGA7 antibody (ab75224) at 1/500 dilution

Lane 1:

COS-7 cells, treated with etoposide (25 µM, 1 hour) at 5 µg

Lane 2:

COS-7 cells, treated with etoposide (25 µM, 1 hour) at 5 µg with Cl-peptide

Predicted band size: 129 kDa

Observed band size: 26 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

African green monkey, Human

アプリケーション

WB, ELISA, IHC-P, IHC-Fr

applications

免疫原

Synthetic Peptide within Human ITGA7. The exact immunogen used to generate this antibody is proprietary information.

Q13683

特異性

ab75224 detects endogenous levels of a fragment of activated ITGA7 resulting from cleavage adjacent to Glu959.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IHCP" : {"fullname" : "Immunohistochemistry paraffin embedded sections", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "See Abreview.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "African green monkey": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "for the full length protein.", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "See Abreview.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab75224 affinity purified from rabbit antiserum by affinity chromatography usingan epitope specific immunogen.

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ITGA7 also known as integrin alpha 7 is a transmembrane protein that plays an important role in cell adhesion and signaling. Weighing approximately 124 kDa ITGA7 is part of the integrin family of proteins functioning as a receptor that binds primarily to extracellular matrix proteins such as laminins. It is expressed largely in skeletal and cardiac muscle tissues but research shows its presence in other tissues like the nervous system.

Biological function summary

ITGA7 interacts with the beta-1 integrin subunit to form a heterodimeric receptor. This combination mediates cell-matrix adhesion promoting cell migration differentiation and survival. ITGA7 is also involved in the stabilization of mature muscle cells and development of muscle fibers. By engaging with specific laminin isoforms ITGA7 influences tissue architecture and function.

Pathways

Researchers recognize that ITGA7 is important in signaling pathways like the PI3K/Akt pathway which affects cell growth and survival. ITGA7 interacts with proteins like focal adhesion kinase (FAK) to transmit signals from the extracellular matrix to the inside of the cell. This communication helps regulate cellular responses and adaptability in dynamic environments.

ITGA7 has connections to muscular dystrophy and certain types of cancer. Mutations or altered expression of ITGA7 can lead to muscular dystrophy where muscle function becomes compromised. In cancer altered ITGA7 expression may affect tumor progression and metastasis with connections to proteins such as dystroglycan. Understanding these relationships is essential for developing targeted therapeutic interventions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

See full target information ITGA7

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:109351 PubMed38495825

2024

Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Gao,Wei Yao,Rui Zhou,Zuowei Pei

Journal of the American Heart Association 11:e026494 PubMed36444867

2022

Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Enrico Bugiardini,Andreia M Nunes,Ariany Oliveira-Santos,Marisela Dagda,Tatiana M Fontelonga,Pamela Barraza-Flores,Alan M Pittman,Jasper M Morrow,Matthew Parton,Henry Houlden,Perry M Elliott,Petros Syrris,Roderick P Maas,Mohammed M Akhtar,Benno Küsters,Joost Raaphorst,Meyke Schouten,Erik-Jan Kamsteeg,Baziel van Engelen,Michael G Hanna,Rahul Phadke,Luis R Lopes,Emma Matthews,Dean J Burkin

British journal of cancer 125:983-993 PubMed34253873

2021

Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response.

Applications

Unspecified application

Species

Unspecified reactive species

Noha Gwili,Stacey J Jones,Waleed Al Amri,Ian M Carr,Sarah Harris,Brian V Hogan,William E Hughes,Baek Kim,Fiona E Langlands,Rebecca A Millican-Slater,Arindam Pramanik,James L Thorne,Eldo T Verghese,Geoff Wells,Mervat Hamza,Layla Younis,Nevine M F El Deeb,Thomas A Hughes

Development (Cambridge, England) 146: PubMed31371375

2019

Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development.

Applications

Unspecified application

Species

Unspecified reactive species

Maqsood Ahmed,Leandro N Marziali,Ernest Arenas,M Laura Feltri,Charles Ffrench-Constant

American journal of physiology. Regulatory, integr 306:R837-44 PubMed24671243

2014

Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques.

Applications

Unspecified application

Species

Unspecified reactive species

Liz Simon,Nicole LeCapitaine,Paul Berner,Curtis Vande Stouwe,Jason C Mussell,Timothy Allerton,Stefany D Primeaux,Jason Dufour,Steve Nelson,Gregory J Bagby,William Cefalu,Patricia E Molina

Molecular therapy : the journal of the American So 21:520-5 PubMed23319059

2013

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.

Applications

Unspecified application

Species

Human

Kristin N Heller,Chrystal L Montgomery,Paul Ml Janssen,K Reed Clark,Jerry R Mendell,Louise R Rodino-Klapac

View all publications

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Abcam product promise

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Anti-ITGA7 抗体

Anti-ITGA7 antibody

Western blot - Anti-ITGA7 antibody (AB75224)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (6)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise