AB5603

Anti-IRS1 抗体

Anti-IRS1 antibody

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(39 Publications)

Rabbit Polyclonal IRS1 antibody. Suitable for WB, ICC/IF and reacts with Mouse samples. Cited in 39 publications. Immunogen corresponding to Synthetic Peptide within Human Insulin receptor substrate 1 aa 600-650.

別名を表示する

Insulin receptor substrate 1, IRS-1, IRS1

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse

アプリケーション

WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human Insulin receptor substrate 1 aa 600-650. The exact immunogen used to generate this antibody is proprietary information.

P35568

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Reactivity data

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下記製品もご検討ください

AB40777

Anti-IRS1+IRS2 antibody [EP263Y]

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こちらの製品も推奨する理由

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

Preservative: 0.05% Sodium azide Constituents: 99% PBS, 0.1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein IRS1 also known as Insulin Receptor Substrate 1 is an important player in insulin signaling. It is a docking protein that plays a part in the signaling pathway of insulin and insulin-like growth factor (IGF) contributing to glucose homeostasis. The molecular weight of IRS1 is approximately 180 kDa. Expressed in various tissues including muscle liver and adipose tissue IRS1 facilitates the transmission of signals from activated cell surface receptors to intracellular pathways. Notable for its phosphorylation IRS1 undergoes change in state when interacting with receptor kinases impacting its role in cell signaling.

Biological function summary

IRS1 helps mediate the effects of insulin by acting as a downstream effector in the insulin signaling cascade. IRS1 functions in a complex manner binding with PI3K (phosphoinositide 3-kinase) after phosphorylation at specific tyrosine residues. This interaction is important for further signaling events leading to the regulation of glucose uptake lipid synthesis and gene expression. Besides its role in energy balance IRS1 plays a significant part in cell growth and differentiation driven by its ability to relay signals from the insulin and IGF receptors.

Pathways

IRS1 is heavily involved in the insulin signaling pathway and the PI3K-Akt pathway. Upon phosphorylation IRS1 binds to proteins such as the PI3K initiating a cascade that ultimately activates Akt resulting in anabolic processes within cells. The pathway is essential for regulating basic functions like metabolism growth and survival. IRS1's interaction with other related proteins like IR (insulin receptor) and IGFR (insulin-like growth factor receptor) highlights its integrative role in cellular processes related to energy and growth.

IRS1 is implicated in insulin resistance and type 2 diabetes. Changes in IRS1 phosphorylation patterns can disrupt normal insulin signaling leading to impaired glucose uptake and metabolic dysregulation. The protein's dysfunction is linked to obesity forming a connection through its interactions with other proteins like Akt and mTOR. Aberrant IRS1 activity may contribute to altered cell metabolism and growth promoting conditions like diabetes which highlights the importance of IRS1 in maintaining metabolic health.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed : 7541045, PubMed : 33991522, PubMed : 38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed : 19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed : 11171109, PubMed : 8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed : 24616100).

See full target information Insulin receptor substrate 1

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文献 (39)

Recent publications for all applications. Explore the full list and refine your search

Cell biology international 48:46-59 PubMed37750505

2023

Pachymic acid (PA) inhibits ferroptosis of cardiomyocytes via activation of the AMPK in mice with ischemia/reperfusion-induced myocardial injury.

Applications

Unspecified application

Species

Unspecified reactive species

Dongmin Liu,Jiru Ding,Zhenzhen Li,Youquan Lu

Biology open 12: PubMed36504260

2023

Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Martha E Montané-Romero,Ana V Martínez-Silva,Augusto C Poot-Hernández,Diana Escalante-Alcalde

Scientific reports 11:21590 PubMed34732776

2021

Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Gokhan Dalgin,Andrew K Tryba,Ashley P Cohen,Soo-Young Park,Louis H Philipson,Siri Atma W Greeley,Alfredo J Garcia

Cell stem cell 28:1549-1565.e12 PubMed33915080

2021

Principles of signaling pathway modulation for enhancing human naive pluripotency induction.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan Bayerl,Muneef Ayyash,Tom Shani,Yair Shlomo Manor,Ohad Gafni,Rada Massarwa,Yael Kalma,Alejandro Aguilera-Castrejon,Mirie Zerbib,Hadar Amir,Daoud Sheban,Shay Geula,Nofar Mor,Leehee Weinberger,Segev Naveh Tassa,Vladislav Krupalnik,Bernardo Oldak,Nir Livnat,Shadi Tarazi,Shadi Tawil,Emilie Wildschutz,Shahd Ashouokhi,Lior Lasman,Varda Rotter,Suhair Hanna,Dalit Ben-Yosef,Noa Novershtern,Sergey Viukov,Jacob H Hanna

STAR protocols 1:100183 PubMed33377077

2020

Protocol to Reprogram Human Menstrual Blood-Derived Stromal Cells to Generate AOX15-iPSCs.

Applications

Unspecified application

Species

Unspecified reactive species

Alicia Sanzhez-Mata,Alberto Ferez-Gomez,Elena Gonzalez-Muñoz

Stem cell research 48:101999 PubMed32971459

2020

L1cam curbs the differentiation of adult-born hippocampal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Marta Grońska-Pęski,Melitta Schachner,Jean M Hébert

Scientific reports 10:7041 PubMed32341445

2020

Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation.

Applications

Unspecified application

Species

Unspecified reactive species

Dasol Han,Mookwang Kwon,Sun Min Lee,Samuel J Pleasure,Keejung Yoon

Communications biology 3:157 PubMed32242137

2020

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara de Lucia,Tytus Murphy,Claire J Steves,Richard J B Dobson,Petroula Proitsi,Sandrine Thuret

Molecular medicine reports 21:2051-2062 PubMed32186775

2020

Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Wang,Lingxia Wang,Jiahui Mao,Huiyan Wen,Longjiang Xu,Yang Ren,Hong Du,Huan Yang

Cell death & disease 10:943 PubMed31819047

2019

Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Seokheon Hong,Jee Hyun Yi,Soonje Lee,Chang-Hwan Park,Jong Hoon Ryu,Ki Soon Shin,Shin Jung Kang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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Anti-IRS1 抗体

Anti-IRS1 antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

下記製品もご検討ください

Anti-IRS1+IRS2 antibody [EP263Y]

こちらの製品も推奨する理由

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (39)

Abcam product promise

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