Anti-IPL-1/STK13/Aurora C 抗体 [EP1011Y] (ab46783)
![Western blot - Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783)](https://www.abcam.co.jp/ps/products/46/ab46783/Images/ab46783-59000-anti-ipl-1-stk13-aurora-c-antibody-ep1011y-western-blot.jpg "Western blot - Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EP1011Y] to IPL-1/STK13/Aurora C
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-IPL-1/STK13/Aurora C antibody [EP1011Y]
IPL-1/STK13/Aurora C 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EP1011Y] to IPL-1/STK13/Aurora C -
由来種
Rabbit -
特異性
This antibody is not recommended in tissue lysate testing.
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アプリケーション
適用あり: WBmore details
適用なし: ICC/IF -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human IPL-1/STK13/Aurora C aa 1-100 (N terminal). The exact sequence is proprietary.
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ポジティブ･コントロール
- HepG2 cell lysate
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EP1011Y -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab46783の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
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| 特記事項 |
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WB
1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). |
追加情報
Is unsuitable for ICC/IF.
ターゲット情報
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機能
May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis. -
組織特異性
Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase. -
関連疾患
Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA. -
配列類似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Contains 1 protein kinase domain. -
細胞内局在
Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis. - Information by UniProt
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参照データベース
- Entrez Gene: 6795 Human
- Omim: 603495 Human
- SwissProt: Q9UQB9 Human
- Unigene: 98338 Human
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別名
- AURKC antibody
- AIE 2 antibody
- Aie1 antibody
see all
画像
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Western blot - Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783)Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783) at 1/1000 dilution + HepG2 lysate at 10 µg
Secondary
goat anti rabbit HRP
Predicted band size: 36 kDa
Observed band size: 36 kDa -
![Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783)](https://www.abcam.co.jp/ps/products/46/ab46783/Images/ab46783-2-benefits-of-recombinant-antibodies.png)
Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783)
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab46783 は 1 報の論文で使用されています。
- Chen L et al. BRDT promotes ovarian cancer cell growth. Cell Death Dis 11:1021 (2020). PubMed: 33257688