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Anti-Interferon gamma 抗体 [B-B1] - BSA and Azide free (ab47343)

Submit a review Q&A (1)
Flow Cytometry - Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)
  • Flow Cytometry - Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)

Key features and details

  • Mouse monoclonal [B-B1] to Interferon gamma - BSA and Azide free
  • Suitable for: Blocking, Flow Cyt
  • Reacts with: Human
  • Isotype: IgG1

製品の概要

  • 製品名

    Anti-Interferon gamma antibody [B-B1] - BSA and Azide free
    Interferon gamma 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [B-B1] to Interferon gamma - BSA and Azide free

  • 由来種

    Mouse

  • 特異性

    ab47343 recognises both natural and recombinant Human Interferon gamma.

    It inhibits Interferon gamma induced proliferation.

  • アプリケーション

    適用あり: Blocking, Flow Cytmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Recombinant full length Human Interferon gamma.

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab47343の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
Blocking
Use at an assay dependent concentration.

ab47343 blocks Interferon gamma-induced proliferation.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
特記事項
Blocking
Use at an assay dependent concentration.

ab47343 blocks Interferon gamma-induced proliferation.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

  • 組織特異性

    Released primarily from activated T lymphocytes.

  • 関連疾患

    In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.

  • 配列類似性

    Belongs to the type II (or gamma) interferon family.

  • 翻訳後修飾

    Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

  • 細胞内局在

    Secreted.
  • Information by UniProt

  • 参照データベース

    • 別名

      • IF 1 antibody
      • IFG antibody
      • IFI antibody
      • ifn g antibody
      • IFN gamma antibody
      • IFN immune antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      • Type II Interferon antibody
      see all

    画像

    • Flow Cytometry - Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)
      Flow Cytometry - Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)

      Flow cytometry analysis of activated lymphocytes labeling B-B1 with ab47343. The dotted line represents the IgG1 isotype control.

    • Flow Cytometry - Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)
      Flow Cytometry - Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)

      Flow cytometry analysis of non-activated lymphocytes labeling B-B1 with ab47343. The dotted line represents the IgG1 isotype control.

    参考文献 (0)

    ab47343 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab47343 は論文での使用が確認できていません。

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    Question

    Hello, I would like to use an anti-interferon antibody in cell culture to block/neutralize IFN gamma. Is this the only such product that comes azide free? If so, this is listed as a blocking antibody but does not have any references... what tests have been done to show that it neutralizes the effects of IFN gamma? Thanks.

    Read More
    Answer

    Thank you for contacting us with your enquiry, and for your patience while I have been in contact with the lab to request more information.

    We do not have any in-house data for this antibody in blocking assays, but I have attached a reference that the lab sent to me. This is the only interferon gamma antibody known to work in a blocking assay thatwe havein an azide-free format.

    I hope this information will be useful, but please let me know if you have any further questions or if there is anything else that we can do for you, and I'll be happy to help.

    Read More

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