AB105669

Anti-Integrin alpha 6 抗体 [GoH3]

Name: Anti-Integrin alpha 6 抗体 [GoH3] (ab105669) | Abcam
Brand: Abcam Limited
SKU: AB105669
Price: 78000 JPY
Availability: InStock
Rating: 4 (6 reviews)

Anti-Integrin alpha 6 antibody [GoH3]

(6 Reviews)

(19 Publications)

Rat Monoclonal Integrin alpha 6 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 19 publications. Immunogen corresponding to Cell preparation containing Itga6 protein.

別名を表示する

CD49f, Integrin alpha-6, CD49 antigen-like family member F, VLA-6, ITGA6

1 Images

Flow Cytometry - Anti-Integrin alpha 6 antibody [GoH3] (AB105669)

Flow Cyt

Unknown

Flow Cytometry - Anti-Integrin alpha 6 antibody [GoH3] (AB105669)

Staining of normal human peripheral blood cells with 0.25 ug of Rat IgG2a Isotype Control Purified (open histogram)or 0.25 ug of Anti-Human/Mouse CD49f (Integrin alpha 6) Purified (filled histogram) followed by Anti-Rat IgG PE Cells in the lymphocyte gate were used for analysis

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

GoH3

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing Itga6 protein. The exact immunogen used to generate this antibody is proprietary information.

Q61739

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br><a href='/products/primary-antibodies/rat-igg2a-kappa-monoclonal-rtk2758-isotype-control-ab18450'>ab18450</a> - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 6 also known as ITGA6 or CD49f functions as a transmembrane receptor protein involved in cell adhesion and signal transduction. As part of the broader integrin family integrin alpha 6 typically pairs with the beta 1 or beta 4 subunits forming the alpha6beta1 or alpha6beta4 integrins respectively. It has a molecular mass of approximately 150 kDa. This protein is mainly expressed in epithelial cells but also found in platelets certain immune cells and in the nervous system. Its expression patterns highlight its role in a variety of cellular and tissue functions.

Biological function summary

The integrin alpha 6 protein partners with the beta 4 subunit to form a heterodimer complex that plays an important role in cellular adhesion to the extracellular matrix specifically interacting with laminins. Its main action helps cells attach to the basement membrane which is an important component of epithelial tissue structure and integrity. The alpha 6 integrin provides structural cell support and participates in transmitting signals that influence cell behavior such as movement survival and proliferation.

Pathways

Integrins including the alpha 6 variant are important components in the integrin signaling pathway and are involved in cell motility and survival pathways. In particular the alpha 6 integrin partners with proteins like focal adhesion kinase (FAK) and phosphoinositide 3-kinase (PI3K) to initiate downstream signaling cascades. The interaction with laminins activates pathways critical for developmental processes and tissue remodeling highlighting their role in maintaining cellular environments.

Integrin alpha 6 has significant implications in cancer progression and skin blistering disorders. In various cancers such as breast and skin cancers upregulation of integrin alpha 6 promotes tumor growth and metastasis through interaction with proteins like collagen and laminins found in the tumor microenvironment. Furthermore in the context of blistering disorders such as epidermolysis bullosa mutations in the beta 4 subunit that pairs with alpha 6 can disrupt the integrity of epithelial tissues leading to severe impact on the skin’s structural stability.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Integrin alpha-6/beta-1 (ITGA6 : ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6 : ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6 : ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 22351760). ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464).

See full target information ITGA6

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文献 (19)

Recent publications for all applications. Explore the full list and refine your search

Nature materials 22:1409-1420 PubMed37709930

2023

The laminin-keratin link shields the nucleus from mechanical deformation and signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Zanetta Kechagia,Pablo Sáez,Manuel Gómez-González,Brenda Canales,Srivatsava Viswanadha,Martín Zamarbide,Ion Andreu,Thijs Koorman,Amy E M Beedle,Alberto Elosegui-Artola,Patrick W B Derksen,Xavier Trepat,Marino Arroyo,Pere Roca-Cusachs

British journal of cancer 128:1742-1752 PubMed36823365

2023

Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value.

Applications

Unspecified application

Species

Unspecified reactive species

André Franken,Annika Kraemer,Alicia Sicking,Meike Watolla,Mahdi Rivandi,Liwen Yang,Jens Warfsmann,Bernhard M Polzer,Thomas W P Friedl,Franziska Meier-Stiegen,Nikolas H Stoecklein,Davut Dayan,Sabine Riethdorf,Volkmar Mueller,Klaus Pantel,André Koch,Andreas D Hartkopf,Natalia Krawczyk,Eugen Ruckhaeberle,Dieter Niederacher,Tanja Fehm,Hans Neubauer

Small methods 6:e2200152 PubMed35451210

2022

Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions.

Applications

Unspecified application

Species

Unspecified reactive species

Sadegh Ghorbani,Ali Shahrokhtash,Julien E Gautrot,Duncan S Sutherland

The Journal of biological chemistry 298:101950 PubMed35447118

2022

Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kiyotaka Kondo,Yoichiro Harada,Miyako Nakano,Takehiro Suzuki,Tomoko Fukushige,Ken Hanzawa,Hirokazu Yagi,Koichi Takagi,Keiko Mizuno,Yasuhide Miyamoto,Naoyuki Taniguchi,Koichi Kato,Takuro Kanekura,Naoshi Dohmae,Kentaro Machida,Ikuro Maruyama,Hiromasa Inoue

Biomaterials 275:120969 PubMed34157563

2021

Insensitivity of dental pulp stem cells migration to substrate stiffness.

Applications

Unspecified application

Species

Unspecified reactive species

Claire Ehlinger,Eric Mathieu,Morgane Rabineau,Vincent Ball,Philippe Lavalle,Youssef Haikel,Dominique Vautier,Leyla Kocgozlu

Development (Cambridge, England) 147: PubMed33144400

2020

Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition.

Applications

Unspecified application

Species

Unspecified reactive species

Dianlei Guo,Jiali Ru,Fuxiang Mao,Hong Ouyang,Rong Ju,Kaili Wu,Yizhi Liu,Chunqiao Liu

Stem cell research & therapy 10:382 PubMed31842987

2019

Relative safety of various spermatogenic stem cell purification methods for application in spermatogenic stem cell transplantation.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Tian,Ke Ma,Cheng-Bin Pei,Shao-Hua Zhang,Xue Li,Yue Zhou,Bei Yan,Hong-Yan Wang,Liang-Hong Ma

Acta neuropathologica 138:1033-1052 PubMed31463571

2019

The dystroglycan receptor maintains glioma stem cells in the vascular niche.

Applications

Unspecified application

Species

Unspecified reactive species

Bryan W Day,Justin D Lathia,Zara C Bruce,Rochelle C J D'Souza,Ulrich Baumgartner,Kathleen S Ensbey,Yi Chieh Lim,Brett W Stringer,Seçkin Akgül,Carolin Offenhäuser,Yuchen Li,Paul R Jamieson,Fiona M Smith,Courtney L R Jurd,Thomas Robertson,Po-Ling Inglis,Zarnie Lwin,Rosalind L Jeffree,Terrance G Johns,Krishna P L Bhat,Jeremy N Rich,Kevin P Campbell,Andrew W Boyd

Methods in molecular biology (Clifton, N.J.) 1926:77-84 PubMed30742264

2019

3D Cell Culture Models of Epithelial Tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Zhang,Aki Manninen

Journal of virology 91: PubMed27974569

2017

Human Adenovirus Type 37 Uses αβ and αβ Integrins for Infection of Human Corneal Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Rickard J Storm,B David Persson,Lars Nygård Skalman,Lars Frängsmyr,Mona Lindström,Greg Rankin,Richard Lundmark,Fatima Pedrosa Domellöf,Niklas Arnberg

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha 6 抗体 [GoH3]

Anti-Integrin alpha 6 antibody [GoH3]

Flow Cytometry - Anti-Integrin alpha 6 antibody [GoH3] (AB105669)

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Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (19)

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Abcam product promise