Anti-Integrin alpha 5 抗体 [5H10-27 (MFR5)]
Anti-Integrin alpha 5 antibody [5H10-27 (MFR5)]
4
(2 Reviews)
|
(10 Publications)
Rat Monoclonal Integrin alpha 5 antibody. Suitable for Flow Cyt, FuncS, ICC/IF, IHC-Fr and reacts with Mouse samples. Cited in 10 publications. Immunogen corresponding to Cell preparation containing Integrin alpha-5 protein.
別名を表示する
CD49e, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, Itga5
- Flow Cyt
Supplier Data
Flow Cytometry - Anti-Integrin alpha 5 antibody [5H10-27 (MFR5)] (AB25251)
C57BL/6 mouse bone marrow cells were stained with Rat Anti-Mouse CD49e-UNLB followed by Goat Anti-Rat IgG(H+L), Mouse ads-PE. X‑axis (horizontal) : Fluorescence Intensity (PE). Y‑axis (vertical) : Cell Count. The grey peak is the isotype control (Rat IgG2a-UNLB) while the purple peak is the positive dataset.
関連する標識済み抗体及び組成の異なる製品 (3)
-
519 FITC
FITC Anti-Integrin alpha-5 antibody [5H10-27 (MFR5)]
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578 PE
PE Anti-Integrin alpha-5 antibody [5H10-27 (MFR5)]
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387 mFluor™ UV375
mFluor™ UV375 Anti-CD49e antibody [5H10-27 (MFR5)]
Reactivity data
製品の詳細
Soluble ab25251 inhibits VLA5-mediated functions in vitro. Immobilized ab25251 has also been demonstrated to co-stimulate the proliferative response of CD8+ T cells to plate-bound antiCD3 monoclonal antibody.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
出荷温度及び保存条件
製品の状態
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Integrin alpha 5 plays a significant role in cellular processes such as migration proliferation and differentiation. It pairs with beta 1 integrin to form the alpha 5 beta 1 integrin complex. This complex facilitates the transmission of mechanical and chemical signals between the extracellular matrix and the cell interior. Integrin alpha 5 also interacts with intracellular proteins like talin and kindlin which are essential for initiating and strengthening the linkage to the actin cytoskeleton.
Pathways
Integrin alpha 5 is involved in the regulation of several critical signaling pathways. It prominently features within the MAPK/ERK pathway and the focal adhesion signaling pathway. Through these pathways integrin alpha 5 influences cell survival proliferation and migration. It interacts with proteins such as paxillin and focal adhesion kinase (FAK) within these pathways contributing to cellular responses to external stimuli.
製品プロトコール
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ターゲットの情報
文献 (10)
Recent publications for all applications. Explore the full list and refine your search
Journal of biomedical materials research. Part A 108:923-937 PubMed31895490
2020
Applications
Unspecified application
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Unspecified reactive species
International journal of molecular sciences 20: PubMed31252620
2019
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Unspecified application
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Unspecified reactive species
International journal of molecular medicine 38:737-46 PubMed27460641
2016
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Unspecified application
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Human
Osteoarthritis and cartilage 24:534-43 PubMed26497608
2015
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Unspecified application
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Unspecified reactive species
Journal of cell science 125:1666-72 PubMed22328507
2012
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Unspecified application
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Unspecified reactive species
Journal of immunology (Baltimore, Md. : 1950) 157:2916-23 PubMed8816397
1996
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Unspecified application
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Unspecified reactive species
Clinical & experimental metastasis 14:125-37 PubMed8605726
1996
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Unspecified application
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Unspecified reactive species
Journal of immunology (Baltimore, Md. : 1950) 155:4567-74 PubMed7594454
1995
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Unspecified application
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Unspecified reactive species
The Journal of biological chemistry 270:11522-31 PubMed7538116
1995
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Unspecified application
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Unspecified reactive species
Blood cells 20:25-44 PubMed7527678
1994
Applications
Unspecified application
Species
Unspecified reactive species
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