Anti-Integrin alpha 3b 抗体 [54B3] (ab8988)
Key features and details
- Mouse monoclonal [54B3] to Integrin alpha 3b
- Suitable for: ICC, WB, IHC-Fr
- Reacts with: Human
- Isotype: IgG1
製品の概要
-
製品名
Anti-Integrin alpha 3b antibody [54B3] -
製品の詳細
Mouse monoclonal [54B3] to Integrin alpha 3b -
由来種
Mouse -
特異性
Recognizes specifically the cytoplasmic domain of integrin subunit a3B which is present in microvascular structures in brain and heart. -
アプリケーション
適用あり: ICC, WB, IHC-Frmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Integrin alpha 3b conjugated to keyhole limpet haemocyanin.
Database link: P26006 -
エピトープ
Cytoplasmic domain of a3B Integrin. -
特記事項
The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
-
精製度
Protein G purified -
一次抗体 備考
The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix. -
ポリ/モノ
モノクローナル -
クローン名
54B3 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG1 -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8988の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC |
Use at an assay dependent concentration.
|
|
WB |
Use at an assay dependent concentration.
|
|
IHC-Fr |
Use at an assay dependent concentration.
|
特記事項 |
---|
ICC
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
ターゲット情報
-
関連性
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. -
細胞内局在
Cell Membrane -
参照データベース
- Entrez Gene: 3675 Human
- SwissProt: P26006 Human
-
別名
- CD49C antibody
- GAPB3 antibody
- Integrin alpha-3 heavy chain antibody
see all
プロトコール
データシートおよび資料
-
Datasheet download
参考文献 (7)
ab8988 は 7 報の論文で使用されています。
- Riabinin A et al. Trajectory of hiPSCs derived neural progenitor cells differentiation into dermal papilla-like cells and their characteristics. Sci Rep 13:14213 (2023). PubMed: 37648686
- Parsegian A et al. Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes. Front Psychiatry 13:1024617 (2022). PubMed: 36311521
- Khalkar P et al. Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis. Free Radic Biol Med 117:247-257 (2018). WB ; Human . PubMed: 29438720
- Tobiasson M et al. Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease. Oncotarget 8:28812-28825 (2017). PubMed: 28427179
- Zhang K et al. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol 383:15-27 (2013). PubMed: 24036311
- Ipenberg I et al. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem 288:14681-7 (2013). PubMed: 23589305
- Kim A et al. Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol 27:1271-9 (2007). PubMed: 17158930