Anti-Integrin alpha 3 抗体 [F35 177-1] (ab20140)
Key features and details
- Mouse monoclonal [F35 177-1] to Integrin alpha 3
- Suitable for: IHC-Fr, IHC-FoFr
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Integrin alpha 3 antibody [F35 177-1]
Integrin alpha 3 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [F35 177-1] to Integrin alpha 3 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Fr, IHC-FoFrmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human Integrin alpha 3. MTSV1-7 HYE - human breast epithelial cells
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特記事項
Fusion Partner: NS2The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
F35 177-1 -
アイソタイプ
IgG1 -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab20140の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-Fr | (1) |
Use at an assay dependent concentration. Fix with acetone.
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IHC-FoFr |
Use at an assay dependent concentration.
|
特記事項 |
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IHC-Fr
Use at an assay dependent concentration. Fix with acetone. |
IHC-FoFr
Use at an assay dependent concentration. |
ターゲット情報
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機能
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. -
組織特異性
Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
翻訳後修飾
Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3675 Human
- Omim: 605025 Human
- SwissProt: P26006 Human
- Unigene: 265829 Human
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別名
- AA407068 antibody
- Antigen identified by monoclonal antibody J143 antibody
- CD49 antigen like family member C antibody
see all
画像
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Immunohistochemistry (Frozen sections) analysis of human skin tissue sections labeling Integrin alpha 3 with ab20140 at 1/1000 dilution. An undiluted goat anti-mouse polyclonal alkaline phosphatase conjugate was used as the secondary antibody.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab20140 は 1 報の論文で使用されています。
- Lustosa SA et al. Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination. ScientificWorldJournal 2014:102541 (2014). IHC ; Human . PubMed: 24737953