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AB228425

Anti-Integrin alpha 3 抗体 [ASC-1]

Anti-Integrin alpha 3 antibody [ASC-1]

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(1 Publication)

Mouse Monoclonal Integrin alpha 3 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing ITGA3 protein.

別名を表示する

CD49c, MSK18, ITGA3, Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, VLA-3 subunit alpha, GAPB3

2 Images
Flow Cytometry - Anti-Integrin alpha 3 antibody [ASC-1] (AB228425)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Integrin alpha 3 antibody [ASC-1] (AB228425)

Flow cytometric analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cell line labeling Integrin alpha 3 with ab228425, GAM-APC (red) compared to a control (grey).

Flow Cytometry - Anti-Integrin alpha 3 antibody [ASC-1] (AB228425)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Integrin alpha 3 antibody [ASC-1] (AB228425)

Flow cytometric analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cell line labeling Integrin alpha 3 with ab228425, PE (red) compared to a control (blue).

関連する標識済み抗体及び組成の異なる製品 (1)

  • 578 PE

    PE Anti-Integrin alpha 3 antibody [ASC-1]

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

ASC-1

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing ITGA3 protein. The exact immunogen used to generate this antibody is proprietary information.

P26006

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
Purity: > 95% (by SDS-PAGE). Purified from TCS.
バッファー組成
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 3 also known as ITGA3 or alpha 3 is a protein that plays an important role in cell adhesion and signaling. It forms complexes with other integrins to mediate interactions between cells and the extracellular matrix. Integrin alpha 3 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. This protein is primarily expressed in epithelial tissues including the skin kidneys and respiratory tract.
Biological function summary

Integrin alpha 3 functions as a cell surface receptor that helps regulate cell migration proliferation and differentiation. It is a part of the alpha-3-beta-1 integrin complex which interacts with extracellular proteins like laminin-5 and collagen. This interaction facilitates the transmission of signals from the outside to the inside of the cell affecting various cellular responses and activities.

Pathways

Integrin alpha 3 plays a significant role in the cell signaling and communication pathways. It is involved in the pathways like focal adhesion and MAPK signaling. In these pathways integrin alpha 3 interacts with other proteins such as paxillin and FAK (focal adhesion kinase) which are critical for the downstream signaling that regulates cell shape and movement.

Integrin alpha 3 is linked to conditions like skin blistering diseases and cancers particularly those affecting the epithelial tissues. Alterations in integrin alpha 3 expression or function can disturb cell adhesion leading to diseases like epidermolysis bullosa. Additionally in cancer integrin alpha 3 often collaborates with proteins like MMP-9 to promote tumor invasion and metastasis.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.. (Microbial infection) Integrin ITGA3 : ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
See full target information ITGA3
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 9:e20591 PubMed37860535

2023

Fecal microbiota transplantation regulates TFH/TFR cell imbalance via TLR/MyD88 pathway in experimental autoimmune hepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Ma,Jianguo Song,Xueping Chen,Duan Dai,Jianping Chen,Liwen Zhang
View all publications
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代替製品

Primary Antibodies

AB242196

Anti-Integrin alpha 3 antibody [CL6937]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 3 antibody [CL6937] (AB242196)

  • 0
  • 0
Primary Antibodies

AB20141

Anti-Integrin alpha 3 antibody [IA3]

  • 0
  • 0
Primary Antibodies

AB223661

Anti-Integrin alpha 3 antibody

Western blot - Anti-Integrin alpha 3 antibody (AB223661)

  • 0
  • 0
Primary Antibodies

AB131055

Anti-Integrin alpha 3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 3 antibody (AB131055)

  • 3
  • 3
Primary Antibodies

AB190731

Anti-Integrin alpha 3 antibody

Western blot - Anti-Integrin alpha 3 antibody (AB190731)

  • 4
  • 7
Primary Antibodies

AB20140

Anti-Integrin alpha 3 antibody [F35 177-1]

Immunohistochemistry (Frozen sections) - Anti-Integrin alpha 3 antibody [F35 177-1] (AB20140)

  • 5
  • 1
Primary Antibodies

AB30488

FITC Anti-Integrin alpha 3 antibody [17C6]

  • 0
  • 0
Primary Antibodies

AB181432

Anti-Integrin alpha 3 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 3 antibody - C-terminal (AB181432)

  • 0
  • 0
Primary Antibodies

AB133198

Anti-Integrin alpha 3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 3 antibody (AB133198)

  • 0
  • 0

組合せ製品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB30394

Anti-Integrin beta 1 antibody [12G10]

KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 1 antibody [12G10] (AB30394)

  • 5
  • 9
Primary Antibodies

AB179475

Anti-Integrin alpha V antibody [EPR16800]

RabMAb|Recombinant

Western blot - Anti-Integrin alpha V antibody [EPR16800] (AB179475)

  • 5
  • 10
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230

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