Anti-Integrin alpha 2 抗体 [HAS-3] (ab10800)
Key features and details
- Mouse monoclonal [HAS-3] to Integrin alpha 2
- Suitable for: IHC-P, IHC-Fr, Flow Cyt, IP, ICC/IF
- Reacts with: Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-Integrin alpha 2 antibody [HAS-3]
Integrin alpha 2 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [HAS-3] to Integrin alpha 2 -
由来種
Mouse -
アプリケーション
適用あり: IHC-P, IHC-Fr, Flow Cyt, IP, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human Integrin alpha 2. Whole human keratinocytes.
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特記事項
The antibody co-precipitates alpha 2 beta 1 integrin from keratinocytes and inhibits HGF induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
一次抗体 備考
The antibody co-precipitates alpha 2 beta 1 integrin from keratinocytes and inhibits HGF induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen. -
ポリ/モノ
モノクローナル -
クローン名
HAS-3 -
ミエローマ
Sp2 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab10800の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (1) |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
|
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Flow Cyt |
Use at an assay dependent concentration.
|
|
IP |
Use at an assay dependent concentration.
|
|
ICC/IF | (2) |
Use at an assay dependent concentration.
|
特記事項 |
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IHC-P
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3673 Human
- Omim: 192974 Human
- SwissProt: P17301 Human
- Unigene: 482077 Human
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別名
- BR antibody
- CD 49b antibody
- CD49 antigen like family member B antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (7)
ab10800 は 7 報の論文で使用されています。
- Hughes JH et al. Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues. Matrix Biol 85-86:112-127 (2020). PubMed: 31189077
- Xing Y et al. Regulation of opticin on bioactivity of retinal vascular endothelial cells cultured in collagen. Int J Ophthalmol 13:1202-1209 (2020). PubMed: 32821673
- van Leenders GJ et al. Activation of c-MET Induces a Stem-Like Phenotype in Human Prostate Cancer. PLoS One 6:e26753 (2011). IHC-Fr ; Human . PubMed: 22110593
- Singh SR et al. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? Am J Physiol Lung Cell Mol Physiol 299:L169-83 (2010). ICC/IF ; Human . PubMed: 20435685
- Alford D et al. Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels. J Cell Sci 111 Pt 4:521-32 (1998). PubMed: 9443900
- Sugiyama M et al. Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinomas. Carcinogenesis 14:2171-6 (1993). PubMed: 7693359
- Tenchini ML et al. Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes. Cell Adhes Commun 1:55-66 (1993). PubMed: 7521749