AB34445

Anti-Integrin alpha 1 抗体 [TS2/7]

Name: Anti-Integrin alpha 1 抗体 [TS2/7] (ab34445) | Abcam
Brand: Abcam Limited
SKU: AB34445
Price: 65000 JPY
Availability: InStock
Rating: 3 (1 reviews)

Anti-Integrin alpha 1 antibody [TS2/7]

(1 Review)

(3 Publications)

Mouse Monoclonal Integrin alpha 1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing ITGA1 protein.

別名を表示する

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

1 Images

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

Flow Cyt

Unknown

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

Staining of HeLa cells with MOUSE ANTI HUMAN CD49a (ab34445).

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

TS2/7

アイソタイプ

IgG1

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing ITGA1 protein. The exact immunogen used to generate this antibody is proprietary information.

P56199

特異性

ab34445 recognises alpha 1 integrin subunit.

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/25 - 1/50", "FlowCyt-species-notes": "Use 10μl of the suggested working dilution to label 106 cells in 100μl.<a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody." } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

Purified from tissue culture supernatant.

バッファー組成

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.

Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

See full target information ITGA1

style

left-column

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

PloS one 11:e0148906 PubMed26848974

2016

Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Rakesh Verma,Madhusudan Venkatareddy,Anne Kalinowski,Sanjeevkumar R Patel,Puneet Garg

Oncotarget 7:5289-305 PubMed26700621

2015

VE-cadherin cleavage by ovarian cancer microparticles induces β-catenin phosphorylation in endothelial cells.

Applications

Species

Unspecified reactive species

Hamda Al Thawadi,Nadine Abu-Kaoud,Haleema Al Farsi,Jessica Hoarau-Véchot,Shahin Rafii,Arash Rafii,Jennifer Pasquier

The Journal of clinical investigation 124:3295-310 PubMed24983314

2014

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.

Applications

Flow Cyt, IHC-Fr

Species

Human, Human

Xiwu Chen,Hongtao Wang,Hong-Jun Liao,Wen Hu,Leslie Gewin,Glenda Mernaugh,Sheng Zhang,Zhong-Yin Zhang,Lorenzo Vega-Montoto,Roberto M Vanacore,Reinhard Fässler,Roy Zent,Ambra Pozzi

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha 1 抗体 [TS2/7]

Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

Abcam product promise