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AB243033

Anti-Integrin alpha 1 抗体 [CL7217]

Anti-Integrin alpha 1 antibody [CL7217]

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(2 Publications)

Mouse Monoclonal Integrin alpha 1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA1 aa 700-750.

別名を表示する

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)

Paraffin-embedded human placenta tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)

Paraffin-embedded human stomach tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)

Paraffin-embedded human prostate tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7217] (AB243033)

Negative Control :

Paraffin-embedded human skeletal muscle tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

CL7217

アイソタイプ

IgG1

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human ITGA1 aa 700-750. The exact immunogen used to generate this antibody is proprietary information.

P56199

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代替製品

Primary Antibodies

AB200570

Anti-Integrin alpha 1 antibody

Western blot - Anti-Integrin alpha 1 antibody (AB200570)

  • 0
  • 0
Primary Antibodies

AB34176

FITC Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

  • 0
  • 0
Primary Antibodies

AB181434

Anti-Integrin alpha 1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

  • 0
  • 1
Primary Antibodies

AB34445

Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

  • 3
  • 1
Primary Antibodies

AB243032

Anti-Integrin alpha 1 antibody [CL7207]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody [CL7207] (AB243032)

  • 5
  • 1

組合せ製品

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
Primary Antibodies

AB129202

Anti-CD103 antibody [EPR4166(2)]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD103 antibody [EPR4166(2)] (AB129202)

  • 5
  • 8
Primary Antibodies

AB179471

Anti-Integrin beta 1 antibody [EPR16895]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 1 antibody [EPR16895] (AB179471)

  • 5
  • 5
Primary Antibodies

AB181548

Anti-Integrin alpha 2 antibody [EPR17338] - C-terminal

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Integrin alpha 2 antibody [EPR17338] - C-terminal (AB181548)

  • 5
  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2500 - 1/5000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
Purified from TCS.
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.
Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
See full target information ITGA1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:678670 PubMed34504839

2021

Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaobo Zheng,Peng Wang,Li Li,Jing Yu,Chune Yu,Liangliang Xu,Lian Li,Fuzhen Dai,Lei Feng,Hong Zou,Xiaobo Chen,Ming Zhang,Mingqing Xu

PLoS pathogens 16:e1008792 PubMed32813746

2020

Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Carmen Romero-Medina,Assunta Venuti,Giusi Melita,Alexis Robitaille,Maria Grazia Ceraolo,Laura Pacini,Cecilia Sirand,Daniele Viarisio,Valerio Taverniti,Purnima Gupta,Mariafrancesca Scalise,Cesare Indiveri,Rosita Accardi,Massimo Tommasino
View all publications
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Abcam product promise

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