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AB118418

Anti-INPP5A 抗体

Anti-INPP5A antibody

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(2 Publications)

Rabbit Polyclonal INPP5A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INPP5A aa 100-350.

別名を表示する

5PTASE, INPP5A, Inositol polyphosphate-5-phosphatase A, 43 kDa inositol polyphosphate 5-phosphatase, 5PTase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5A antibody (AB118418)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5A antibody (AB118418)

ab118418, at 1/100 dilution, staining INPPA5 in paraffin-embedded Human fetal spleen tissue by Immunohistochemistry.

Western blot - Anti-INPP5A antibody (AB118418)
  • WB

Unknown

Western blot - Anti-INPP5A antibody (AB118418)

All lanes:

Western blot - Anti-INPP5A antibody (ab118418) at 1/500 dilution

Lane 1:

Human fetal brain lysate

Lane 2:

Human fetal heart lysate

Lane 3:

Human fetal lung lysate

Lane 4:

Human fetal colon lysate

Predicted band size: 48 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human INPP5A aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

Q14642

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組合せ製品

Primary Antibodies

AB124781

Anti-Histone H2A antibody [EPR895] - Nuclear Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H2A antibody [EPR895] - Nuclear Marker (AB124781)

  • 5
  • 5
Primary Antibodies

AB243906

Anti-gamma H2A.X (phospho S139) antibody [BLR053F]

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-gamma H2A.X (phospho S139) antibody [BLR053F] (AB243906)

  • 0
  • 0
Primary Antibodies

AB32049

Anti-p53 antibody [Y5]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p53 antibody [Y5] (AB32049)

  • 4
  • 5
Primary Antibodies

AB175933

Anti-53BP1 antibody [EPR2172(2)]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-53BP1 antibody [EPR2172(2)] (AB175933)

  • 5
  • 3
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Lyophilized
再構成
Reconstitute in 200 µL of water
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab118418 is purified by a protein affinity column.
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

INPP5A also known as Inositol Polyphosphate-5-Phosphatase A plays a role in cellular signaling by dephosphorylating inositol phosphates. The protein has a molecular mass of approximately 44 kDa. This enzyme mainly expresses in the brain and skin tissues where it carries out its signaling functions. INPP5A acts on substrates such as inositol 145-trisphosphate (IP3) and inositol hexakisphosphate participating in the regulation of various signaling pathways.
Biological function summary

INPP5A enzymes regulate calcium signaling and apoptosis through their phosphatase activity. By removing phosphate groups INPP5A enzymes contribute to the termination of inositol phosphate signaling which affects a wide variety of cell processes. This enzyme functions as a singular unit rather than part of a larger enzyme complex allowing it to target inositol phosphates independently. The control of these signaling pathways is important for maintaining proper cellular function and communicating signals within cells.

Pathways

INPP5A contributes to the phosphoinositide signaling pathway and calcium signaling pathway. Its phosphatase activity provides an important regulatory function modulating the levels of inositol phosphates and thereby affecting downstream signaling processes like calcium release. It relates to proteins such as IP3 receptors and other inositol phosphatases emphasizing its role in orchestrating complex signaling networks within cells.

Alterations in INPP5A activity have connections to spinocerebellar ataxia and certain skin disorders like psoriasis. Disrupted INPP5A expression or function can interfere with normal cellular signaling potentially leading to neurological symptoms or skin pathologies. In the context of these diseases INPP5A shows interactions with proteins involved in neurodegeneration and epidermal regulation highlighting its significance in maintaining homeostasis and disease prevention.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed : 8013665, PubMed : 8626616, PubMed : 8769125). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
See full target information INPP5A
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Iranian biomedical journal 26:440-53 PubMed36437782

2022

INPP5A/HLA-G1/IL-10/MMP-21 Axis in Progression of Esophageal Squamous Cell Carcinoma

Applications

Unspecified application

Species

Unspecified reactive species

Sima Ardalan Khales,Azadeh Aarabi,Mohammad Reza Abbaszadegan,Mohammad Mahdi Forghanifard

The Journal of biological chemistry 289:10270-5 PubMed24596094

2014

Importin 8 regulates the transport of mature microRNAs into the cell nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Wei,Limin Li,Dong Wang,Chen-Yu Zhang,Ke Zen
View all publications
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Abcam product promise

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