AB5416

Anti-Influenza A Virus M2 Protein 抗体 [14C2]

Name: Anti-Influenza A Virus M2 Protein 抗体 [14C2] (ab5416) | Abcam
Brand: Abcam Limited
SKU: AB5416
Price: 59000 JPY
Availability: InStock
Rating: 5 (2 reviews)

Anti-Influenza A Virus M2 Protein antibody [14C2]

(2 Reviews)

(81 Publications)

Mouse Monoclonal M2 antibody. Suitable for ICC and reacts with Influenza A samples. Cited in 81 publications.

別名を表示する

Influenza A virus matrix protein M2, Matrix protein 2, Membrane ion channel M2, Membrane protein M2, Proton channel protein M2

1 Images

Unknown

Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (AB5416)

Immunofluorescence staining of infected dog MDCK cells using ab5416.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

14C2

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

交差種

Influenza A

アプリケーション

ICC

applications

エピトープ

Detects the N-terminal of the Influenza A Virus M2 Protein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Influenza A": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1 µg/mL", "ICC-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Influenza A Virus M2 Protein also known as M2 ion channel or matrix protein 2 plays an essential role in the viral life cycle. This protein has a mass of approximately 97 amino acids and is expressed on the envelope of the Influenza A virus. It functions as a proton-selective channel facilitating the acidification of the viral interior after the virus enters the host cell. This acidification process is important for the uncoating of the viral genome allowing subsequent replication of the virus in host cells.

Biological function summary

The M2 protein from Influenza A virus participates in virus assembly budding and release. The protein operates as a tetramer creating a channel across the viral membrane. This channel is essential for the correct function and structure of the virus playing an important role in membrane fusion and release of the viral particles. It often works in conjunction with another matrix protein M1 which assists in stabilizing the integrity of the viral structure.

Pathways

The M2 Influenza protein is integral to the viral replication and assembly pathway. It aligns with the function of the viral ribonucleoprotein complex and is significant in the viral entry and exit pathways. Additionally the connection to the M1 matrix protein highlights its coordinated role in facilitating the assembly and release of new virions from the infected cells emphasizing its necessity in productive viral replication.

The Influenza A virus M2 protein is directly related to the pathogenesis of seasonal influenza. Antiviral drugs like amantadine and rimantadine target this ion channel to disrupt viral replication. Resistance mutations in the M2 protein can influence the efficacy of these drugs impacting treatment outcomes. There is also a link with immune system responses where M2 interactions with other viral proteins can modulate host immune evasion mechanisms.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information Influenza A Virus M2 Protein

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文献 (81)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadu7602 PubMed40498831

2025

Influenza A virus subverts the LC3-pericentrin dynein adaptor complex for host cytoplasm entry.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Cong,Pauline Verlhac,Benjamin B Green,Jacqueline de Vries-Idema,Line Moesgaard Strauss,Clàudia Río-Bergé,Anders Etzerodt,Lene N Nejsum,Anke L W Huckriede,Fulvio Reggiori

Viruses 16: PubMed39205283

2024

The M2 Protein of the Influenza A Virus Interacts with PEX19 to Facilitate Virus Replication by Disrupting the Function of Peroxisome.

Applications

Unspecified application

Species

Unspecified reactive species

Tanbin Liu,Libin Liang,Pu Zhao,Weipeng Lin,Yichao Zhuang,Li Jiang,Hualan Chen,Chengjun Li

Nature communications 15:6802 PubMed39122688

2024

Engineered probiotic Escherichia coli elicits immediate and long-term protection against influenza A virus in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Huang,Wei Tang,Lina He,Mengke Li,Xian Lin,Ao Hu,Xindi Huang,Zhouyu Wu,Zhiyong Wu,Shiyun Chen,Yangbo Hu

Frontiers in microbiology 15:1423995 PubMed39035445

2024

Intracellular develops enhanced fluoroquinolone persistence during influenza A coinfection.

Applications

Unspecified application

Species

Unspecified reactive species

Mirelys Hernandez-Morfa,Nicolas M Reinoso-Vizcaino,Victoria E Zappia,Nadia B Olivero,Paulo R Cortes,Cinthia C Stempin,Daniel R Perez,Jose Echenique

JACC. Basic to translational science 7:1214-1228 PubMed36644282

2022

Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Evans,Xiucui Ma,Xiqiang Wang,Yana Chen,Chen Zhao,Carla J Weinheimer,Attila Kovacs,Brian Finck,Abhinav Diwan,Douglas L Mann

The Journal of cell biology 221: PubMed36169638

2022

PI4P and BLOC-1 remodel endosomal membranes into tubules.

Applications

Unspecified application

Species

Unspecified reactive species

Riddhi Atul Jani,Aurélie Di Cicco,Tal Keren-Kaplan,Silvia Vale-Costa,Daniel Hamaoui,Ilse Hurbain,Feng-Ching Tsai,Mathilde Di Marco,Anne-Sophie Macé,Yueyao Zhu,Maria João Amorim,Patricia Bassereau,Juan S Bonifacino,Agathe Subtil,Michael S Marks,Daniel Lévy,Graça Raposo,Cédric Delevoye

Biophysical journal 120:5478-5490 PubMed34808098

2021

Influenza A M2 recruits M1 to the plasma membrane: A fluorescence fluctuation microscopy study.

Applications

Unspecified application

Species

Unspecified reactive species

Annett Petrich,Valentin Dunsing,Sara Bobone,Salvatore Chiantia

Cell reports 37:109899 PubMed34706226

2021

Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Ulferts,Elena Marcassa,Lewis Timimi,Liam Changwoo Lee,Andrew Daley,Beatriz Montaner,Suzanne Dawn Turner,Oliver Florey,John Kenneth Baillie,Rupert Beale

mBio 12:e0148421 PubMed34517760

2021

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fernando Villalón-Letelier,Andrew G Brooks,Sarah L Londrigan,Patrick C Reading

Viruses 13: PubMed34578289

2021

Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses.

Applications

Unspecified application

Species

Unspecified reactive species

Nutan Mytle,Sonja Leyrer,Jon R Inglefield,Andrea M Harris,Thomas E Hickey,Jacob Minang,Hang Lu,Zhidong Ma,Hanné Andersen,Nathan D Grubaugh,Tina Guina,Mario H Skiadopoulos,Michael J Lacy

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Influenza A Virus M2 Protein 抗体 [14C2]

Anti-Influenza A Virus M2 Protein antibody [14C2]

Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (AB5416)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

エピトープ

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (81)

組合せ製品

Primary Antibodies

Secondary Antibodies

Sample Prep & Detection Kits

Primary Antibodies

Abcam product promise